Ichiza "Atokor": umyalelo manual, analogu kunye nohlolo

amazinga cholesterol aphezulu kwi-plasma inegalelo kuphuhliso yegazi kunye nesifo sentliziyo inkqubo.

Ukuthwala unyango yandisa lipid kusetyenziswa iindlela ezizodwa, enye yazo kukuthi ichiza "Atokor". Imiyalelo kule iyeza ichaza indima yalo hypocholesterolemic kwaye gipotriglitseridemicheskuyu ekunciphiseni uyondelelwano lwee- cholesterol yingozi kunye nezinye kwamafutha emzimbeni womntu.

iimpawu ngokubanzi

Iyeza ibhekisa inhibitors of reductase-3-methylglutaryl-3-hydroxy-awula. "Iilabhoratri uGqr Reddy kaThixo" lukhutshwe yinkampani Indiya.

Xa Elungiselela "Atokor" idosi kusenokuba 0,020 no 0,010 g

release Form

arhente Iveliswe azipilisi isale esimhlophe umboniso. Amacwecwe extruded enembonakalo unxantathu kunye nomphezulu biconvex kwenye apho ileta "A" uyasetyenziswa, kunye nezinye yonyulwa umthamo we "10" okanye "20".

isakhiwo

Eyona nto elikhutheleyo ichiza atorvastatin, nto leyo efuziselwa micronized calcium trihydrate. Xa amayeza "Atokor" idosi kunye nokwakhiwa esisebenza zamanani ezahlukeneyo kancinane. Wonke 0,01084 okanye 0,02168 g atorvastatin calcium trihydrate elilingana 0,01 okanye 0,02 g atorvastatin ecocekileyo.

Ubisi iswekile, calcium carbonate, isodiyam croscarmellose, polysorbate 80, hydroxypropyl kwincindi, lactose DT, nemagnesium stearate ubume tablet kwakhiwa.

Le film istili wabumba hypromellose CPS-15, propylene ethers, talc nyulu, titanium dioxide.

Okufanayo ithamo zombini kuthetha "Atokor" composition, Uyinyathelise itotali yawo.

Amacwecwe 0,01 okanye 0,02 g lamaqhosha 10 zakhiwa a blister zahlanganiswa kwibhokisi yekhadibhodi.

indlela isenzo

Amayeza umyalelo kwi isicelo sinxulumene uyakhetha, retarders zokhuphiswano 3 methylglutaryl--3-hydroxy-kofermentaA reductase. Kuyinto enzyme ebalulekileyo ukuze nokuguqulwa compound-3-hydroxy-metilglyutarilkoenzima-3 A ku mevalonic acid olungaphambi styrenes kunye cholesterol.

Ukuba kwizigulana hypercholesterolemia, homozygous heterozygous uhlobo kwiintsapho kunye non-kwiintsapho, kunye dyslipidemia engumxube, ubhaliso iziyobisi "Atokor" inceda ukwehlisa cholesterol iyonke, amasuntswana cholesterol kwi lipoproteins of lexinene eliphantsi asezantsi kakhulu, triglycerides kunye apolipoprotein B.

Medicament "Atokor" inkcazelo ichiza lubonisa zinako iipilisi ezingazinzanga luncedo ukunyusa umgangatho sterol xa lipoproteins kunye ezixineneyo.

Xa iiseli kwesibindi, iimolekyuli triglycerides holesterolovye abe yinxalenye izinto lipoprotein ukuba mninzi kakhulu ephantsi. Baya kuthunyelwa plasma, ukugqobhoza kungena inyama peripheral. Of ezi zihlanganisi akha lipoprotein kunye Ukwanda eliphantsi nako asabela catalyzed kunye noFaro high uhlobo receptor namabandla. Zonke ezi zinto ngoyo uphuhliso kwezifo atherosclerotic.

Action Atorvastatin iphawulwa ukonyuka okuphawulekayo kwaye gqolo ukusebenza kwizakhiwo LDL-receptor, ukunciphisa yingozi boxinzelelo cholesterol kwi hypercholesterolemia ephakamileyo uhlobo homozygous zamafa.

Lithetha "Atokor" umyalelo kubonisa ubuchule layo ukuthoba izinga cholesterol plasma kunye lipoprotein ngokuthi ziyibuyisela HMG-onx reductase enzyme. Azikhuli phantsi ukuyilwa cholesterol iiseli isibindi, kwandisa inani kwingxelo receptor of lipoproteins kunye Ukwanda eliphantsi inwebu yeseli. Oku kwandisa bamba catabolism cholesterol evela molekyuli lipoprotein ukuzikisa ingqondo eliphantsi.

Into esetyenzisiweyo

Medicament "Atokor" Umsebenzisi Application ucebisa amacwecwe uthathe iimpawu eziphambili yokwanda cholesterolemia uhlobo heterozygous, ukwandisa cholesterol yoxinaniso zasekuhlaleni kunye non-ndawo, geterlipidemii engumxube, ukwanda imali iimolekyuli plasma triglyceride.

Bona zilawulwa ngokudityaniswa imiyalelo zokutya ukwenzela ukuthoba izinga eliphezulu cholesterol kwi lipoproteins kunye Ukwanda ephantsi, apolipoprotein B kunye nemixube triglyceride.

Iipilisi zokunciphisa plasma lwee- cholesterol LDL cholesterolemia kwi eziphakamileyo uhlobo homozygous kwiintsapho, xa ukutya yokutya kunye nezinye iindlela ezingezo-imithi angasebenzi.

Indlela ukuthatha

Medicament "Atokor" imiyalelo ukusetyenziswa icebisa ukuba ukusela kuphela emva kokuba kuqeshwe ukutya hypocholesterolemic umntu standard lokugula, nekufuneka zisetyenziswe ngexesha unyango. Umthamo umiselwe ngokwahlukileyo ukuze isigulane ngasinye, ebalwayo kwinqanaba lokuqala cholesterol lipoproteins kunye saturation eliphantsi. Kubalulekile ukuthatha ingqalelo ukusetyenziswa ekujoliswe, ukusebenza unyango with "ubungqina Atokor '.

Ngokuqhelekileyo, umthamo wokuqala luyafana 0.010 g ngexesha elinye ngosuku. Ukusetyenziswa kumacwecwe akaxhomekekanga ixesha ukusetyenziswa imini kunye nokutya.

Le umthamo iindlela ngemihla ka-0,010 ukuya 0,080 g kukhethwa nezikhombisi ingxelo lokuqala cholesterol eziyingozi, isakhiwo ekujoliswe kunye nokusebenza zobuqu. Kwisigaba sokuqala kwesicelo kunye ngokwandisa uyondelelwano lwee- ichiza kufuneka ube sisiqingatha ngenyanga khangela inqanaba amanqatha plasma, uze ulungise idosi njengoko kuyimfuneko.

hypercholesterolemia Primary nezidibeneyo hyperlipidemia umlinganiswa ngayo idosi yemihla ngemihla ngo-0,010 g

umsebenzi therapeutic kwenzeka kwiintsuku ezili-14, kwaye ngempumelelo enkulu kunokwenzeka emva kwenyanga enye. sebenzisa ixesha elide kwenza kube lula ukugcina ukusebenza therapeutic.

Imithi "Atokor" kwi manual Russian iqulathe ulwazi terapiigiperholesterinemii lohlobo homozygous kwiintsapho. Ngokuqhelekileyo, emiselweyo idosi yemihla ngemihla 0.080 g Kule ukusetyenziswa linciphileyo LDL amaxabiso cholesterol ukuya kwi-40%.

Iimpawu zonyango

Amacwecwe "imiyalelo Atokor 'ukuba ukusetyenziswa kucetyiswa ngamandla phambi kokuqala ukusebenzisa ichiza kufuneka ukufumana unobangela ukunyuka yesibini amaxabiso cholesterol. Ezi zinto ziquka isifo seswekile, ukuphathwa kakuhle seswekile, hypothyroidism, utshintsho inkqubo disproteinemicheskih nephrotic, isifo sesibindi obstructive. Oku kuquka unyango olunye kunye nezinye iziyobisi likhoboka utywala. Kuphela emva kokuba ndabagxotha zizathu ngasentla, ukulungele ukuba usebenzise icwecwe "Atokor".

Kwanangaphambi uthomalaliso lwenziwa ukumiselwa lipid ukulingana phakathi cholesterol iyonke, LDL cholesterol e-HDL cholesterol kunye triglycerides.

Akukho data ekusetyenzisweni kwamayeza kwinani labemi ezingabantwana, ngoko kwezi tablets bangabi eboniswe abantwana.

Xa unyango izigulane abalupheleyo, ogama ubudala kwiminyaka engaphezu kwama-60, ukunyuka kumanqanaba plasma kwabasebenzi kuza kweli candelo arhente esebenzayo kwi-40%.

Kwimeko zokugxojwa nokusebenza kwezintso akukho mfuneko yokuba amanqaku makalungiswe ithamo, njengoko le meko aluchaphazeli isiqulatho atorvastatinovoe kwi kwemithambo yegazi kunye nokusebenza lisibekele cholesterol embi.

Kukho ubungqina obubonisa ukuba ukusetyenziswa kwale iklasi iziyobisi ukuba myopathy yophuhliso rabdomioliznoy nomsebenzi kidney zaneleyo ngohlobo yayiyazi. Kwezi zifo imithi kufuneka zilahlwe ngelo xesha.

Amalungiselelo ngokwesiseko atorvastatin kufuneka kuthathwe ngenyameko abantu kakubi utywala okanye baye isifo sesibindi ngaphambili.

Isenzo inhibitors of HMG-onx reductase enzyme inokuba utshintsho nezalathisi kwemichiza umsebenzi zesibindi. Kuba ufakelo ngexesha komgomo ezinjalo kufuneka lenze uvavanyo lomsebenzi hepatic, uze iinyanga ezi-3 emva kokuthatha iipilisi ukuphumeza netsheki phambi unyango.

Drug "Atokor" ngokomyalelo Russian luquka ulwazi malunga ukwanda okuphawulekayo amaxabiso plasma le esisebenza izigulane abanesifo sesibindi, abaphethwe butywala. ulwahluleko lwethutyana okanye olupheleleyo unyango ubuyisela umsebenzi transaminase kwesibindi kwisakhelo sokuqala. izigulane abaninzi abazange kuziphelisa ukusetyenziswa kweziyobisi ngeedosi ezincinane, yaye akukho abasabela elibi sazi ukuba lilixa lokugqibela.

Xa unyango Ndinesiyezi, ukuphuhlisa ukozela, ngoko ngexesha lokwenza isicelo lwezigulane iipilisi kuyathintelwa ukulawula uthutho kunye nezinye izixhobo ezintsonkothileyo.

Ngubani kufuneka asebenzise

On medicament "Atokor" Izimo ziquka i uvakalelo awongezelelekileyo okufumana zithako ngalinye medicament.

Akazange athathe kwimeko isifo sisibindi lokuvula eliphezulu transaminase enzayim serum xa umsebenzi sabo amaxesha 3 ngaphezulu kwe nelona qondo liphezulu amaxabiso eziqhelekileyo.

Ichiza ungamiselwanga ukuba namakhosikazi aselekhulile ukuvelisa abo awusebenzisi kukhulelwa ngokwaneleyo. Contraindication yimeko lokuzala kunye nokuncancisa.

Medicine Akasohlwayi abantwana abafikisayo abangaphantsi kweminyaka eli-18 ubudala.

Ngenxa yobukho ubisi ekwakhiweni kwezi tablets 'Atokor "umyalelo neswekile isicelo lithintela ukusetyenziswa nabo ukunyamezelana ilifa kwiimolekyuli galactose, kunye ukunqongophala yelactose kunye glucose-galactose malabsortsii.

analogs

Kukho inani elikhulu lwamachiza ngokusekelwe atorvastatin. Cholesterol-yandisa indima kweziyobisi ku "Atokor" umyalelo manual. Analogs abakwaziyo ukuthoba izinga cholesterol embi egazini.

Enye imithi enjalo yinto unyango kuba Slovenian "Atoris", nto leyo umenzi inkampani kwemfuyo joint "Krka, Novo mesto." Oveliswa ngokohlobo amacwecwe kunye isiqulatho esisebenzayo eziletha 0.010 g, 0.020 g, 0.040 g

Ichiza yenzelwe athintele imeko hyperlipidemic, apho imida kuyimfuneko ukunciphisa cholesterol iyonke, lipoprotein cholesterol iikhompawundi kunye Ukwanda phantsi, isixa apolipoprotein kunye molecule triglyceride umsinga igazi.

imphathe Drug abantu hypercholesterolemia polygenic heterozygous homozygous uhlobo kwiintsapho.

Ngoncedo "Atoris" ichiza kwandisa lwee- cholesterol lipoproteins kunye saturation eliphezulu.

Enye Togu Slovene ingqalelo iziyobisi "eTulip," nto leyo kwenziwa ngoku "Lek Pharmaceutical Company". Kukho iidosi ezintathu amacwecwe bhanya-camera: 0,01 g, 0,02 g and 0.04 g

Ichiza iboniswe lokuphelisa iifom ephambili hypercholesterolemic combined imeko hyperlipidemic, kuba unyango lwe cholesterol eliphakamileyo uyayixabisa heterozygous kunye nohlobo usapho homozygous.

Ngokufanayo, indlela ingqalelo Indian amayeza "Astin", nto leyo yenziweyo lweshishini "Micro Labs Limited". Kuyinto ifumaneka iidosi ezimbini: kwi 0,010 g kunye 0,020 g atorvastatin.

Ichiza kumiselwe kwi isiqulatho lipid ukwanda, xa anayenza iingenelo iziganeko yokutya kunye nezinye.

Indian mveliso a medicament "Storvas" ngokusekelwe calcium ityiwa atorvastatin. Elalenziwe "Ranbaxy Laboratories Limited" ngokohlobo elucwecweni isale esingxotyeni salo kwi iidosi ezimbini: kwi 0,010 g and 0,020 g

Drug "Storvas" ukunciphisa isiqulatho eliphezulu cholesterol iyonke, iimolekyuli LDL cholesterol, kwaye lwee- iikhompawundi apolipoprotein triglyceride eziziiprayimari, kwaye heterozygous imeko hypercholesterolemic kwiintsapho nonmarried, kwakunye nesifo mixed hyperlipidemic.

Amayeza kunciphisa ithuba iposi engabalulekanga karhulumente engabalulekanga mihle kwemisipha, ukufa kwamalungu kunye notshintsho ithombo legazi lobuchopho. Amacwecwe inciphise ukuqhubela phambili imeko coronary atherosclerotic.

umlingani aseMelika ichiza "Lipitor" lukhutshwe "Pfizer". Oveliswa ngokohlobo amacwecwe isale kwiqokobhe kwi iidosi ezintathu: kwi 0.010 g, 0.020 g, 0.040 g Ichiza lukwasetyenziswa kupheliswe ithi hypercholesterolemic kweentlobo ezahlukeneyo imvelaphi.

reviews

ichaza Medicine "Atokor" Umsebenzisi Application njengoko kuthetha kunye ngempumelelo eliphezulu aqinisekisiweyo. Izigulane ezininzi kunye ephakamileyo lamanani plasma cholesterol eziyingozi, emva kwikhondo ukusetyenziswa iba ngcono. Iinqobo ze cholesterol iyonke kunye LDL cholesterol bancipha kwinqanaba eqhelekileyo, oko kunciphisa amathuba okudluliselwa yokuphuhlisa yegazi, kunye neemeko kobuchopho.

Ichiza fanele kumajelo eendaba nge tolerability elungileyo, kodwa ezinye izigulane inokuba njengesihlalo ukulibaziseka, ukuqumba, iintlungu esiswini, isicaphucaphu, ukungacoleki kokutya. Kukho intloko, ukulala aphazamiseka. Inokuphuhlisa ezixhuzuxhuzulayo, asthenic kunye nemeko myalgic.

Kwiimeko ezinqabe kakhulu, iziphumo ebezingalindelekanga myositis abonisa, myopathy, paresthesia, peripheral neuropathy, i-pancreatitis, hepatitis, senyongo cholestatic.

Tablets ingabangela ukudla, ukugabha, obubonakala hepatotoxicity, alopecia, ibonwa pruritic of irhashalala, namandla, cataract, hyper- okanye hypoglycemia.