Glycosides inhliziyo. Yintoni na?

glycosides wentliziyo ziyafana kubume amachiza ukuya inyongo asidi, cortisone, iivithamini, iihomoni, cholesterol. Ezi zinto ke metabolites zendalo ukuba kugcinwe ukusebenza eqhelekileyo kwentliziyo.

glycosides wentliziyo iqanjwa glucone (iswekile) kunye aglycone. It aglycone na izigqibo beziyobisi kumsebenzi imithi. Ukungena asabela kunye nezinye izinto esebenzayo iqinisekisa unsaturated umsesane-membered ezintlanu kubume.

glycosides wentliziyo izicwili kunye amalungu athunyelwa edyokhweni. Nokucetyiweyo izenzo zabo - le myocardium, leyo oluhlala% 10 kuphela kuqulunqo, kongezwe 50% ezisisigxina izihlunu striated apho esingenakubangela naliphi na isiphumo.

Kuba ubude isenzo glycosides kwentliziyo zihlukaniswe:

- elide - digitoxin,

- eliphakathi - digoxin

- mfutshane - strofantin, Korglikon.

glycosides wentliziyo: indlela amanyathelo

Zikarhulumente eziqhelekileyo cardiomyocytes eziqulethwe izihlandlo 30 potassium ngakumbi namaxesha-20 sodium ngaphantsi. Nokuphumla, umphezulu ongaphandle yeseli inwebu le kakuhle ityala, kwaye lwangaphakathi - phezu koko, i negative. Phezu excitation ukuba inwebu depolarization: sodium kunye calcium kungena iseli. Ngethuba lale nkqubo, i-potassium akakwazi kugqitha iseli ndizayo. Kwathi kamsinya nje ukuba ndiphume esiseleni, inkqubo repolarization iqala. Lo mzuzu kwenzeka ngaphambi nje imisipha. Ngenxa yoko, inani ikhalsiyam ungene inika iiseli zokucutha. ion potassium eliseleyo esiseleni, abo babemphikisa yenkqubo.

glycosides wentliziyo, sakhuthalela ekuqaleni repolarization nokubonelela isivuno ubuninzi cardiomyocytes potassium. Emva kokuba ukwehla kwayo kuyimfuneko ukuze kubuyiselwe intsalela ion ngaphakathi nangaphandle iseli (potassium kunye ukubuya sodium hoxa). Le nkqubo kuxhomekeke iiseli amandla Reserve, wayengumlamleli ATP-ase enzyme. indawo yayo esebenzayo - iqela sulfhydryl. glycosides wentliziyo asithe site esebenzayo, ukunciphisa umsebenzi. Konke oku kukhokelela kukuba ion sodium kuhlala esiseleni, yaye oku ibalekisa kokuqala kwekhefu depolarization elandelayo. Ukuba umxholo ion potassium kuya kuncipha kakhulu, ukuba uwaphule Yindibanisela creatine phosphate, nto leyo ekhokelela ukuncipha yamandla yindibanisela izihlunu intliziyo.

glycosides inhliziyo: Izimo

Izimo Absolute yokusebenzisa yabo: atrioventricular block II isidanga, sinus bradycardia, kukwalisa la machiza, ukunxila kubo.

Kuba Izimo isihlobo ezi zilandelayo: bradyarrhythmia ciliary, AV-block I degree, abagulayo sinus syndrome, isifo sentliziyo, sinus bradycardia, lwegazi, intliziyo, hypercalcemia, hypokalemia, kwezintso okanye insufficiency yemiphunga nezengekho imbali.

Bekungalunganga ukusebenzisa glycosides kwentliziyo phantsi kwale miqathango ilandelayo: amyloidosis kwentliziyo, ukuzala ezesifuba umthamo omninzi kunye insufficiency aortic, thyrotoxicosis, iposi etsolo engabalulekanga, cardiomyopathy, pericarditis constrictive, ukusilela intliziyo congestive lo gama kugcinwe imveliso kwentliziyo phezulu, ianemia njalo njalo.

Ngqo bona Izimo ngenxa yokungabikho kwekhono iSystolic, ezichaza nokungasebenzi glycosides inhliziyo. Kwaye, umzekelo, ngexesha uphuhliso iqhosha etsolo engabalulekanga, ukusetyenziswa kungabangela uphuhliso arrhythmias, enika ALS kakuhle ubomi kwakhona yesigulana.

Phambi isicelo glycosides kwentliziyo kufuneka athethane yincutshe. Oku kuya kunceda iyaluthintela uphuhliso iingxaki ezinzulu.