"Azathioprine": umyalelo manual, ncomo, iinkcazelo, analogs

Yeyiphi ikhwelo ichiza "Azathioprine"? Imiyalelo isicelo olwangeniswa yi-arhente ziza kuchazwa kweli nqaku. Siya kunixelela ukuba ingaba kukho Izimo kunye analogue abanalo eli chiza, oko kubiza into, oko kuya kwenzeka kwimeko libanda, njalo njalo. D.

Ubume, ukupakishwa, imilo, inkcazo medicament

Ziziphi fom iziyobisi ezikhoyo "Azathioprine"? Imiyalelo yokusebenzisa licebisa ukuba eli yeza ifumaneka azipilisi. isithako yabo esebenzayo uba azathioprine. Kwakhona eli chiza kwaye ziquka izithako owongezelelweyo ngendlela amazambane wesitatshi, gelatin, lactose, kunye calcium stearate.

Xa iphakheji wathengisa ichiza "Azathioprine"? Imiyalelo yokusebenzisa beziyobisi livalelwe ibhokisi yekhadibhodi, nto leyo ebeka iipilisi baluthuthu Valium atyheli imiqulu blister lamaqhosha 50.

iimpawu amayeza le medicament

Yintoni na le amayeza njengoko 'Azathioprine'? Imiyalelo yokusebenzisa, iingcali yokwenene abanamava uxele ukuba ichiza uchaphazelekayo analog "hypoxanthine", "Adenine" yaye "guanine", kubandakanywa isakhiwo nucleic yaye babonise umoya nefuthe ukuvimbela ngokunxulumene kunyebeleziso inyama neyantlukwano cell.

"Azathioprine" - arhente immunosuppressive. wesenzo sijoliswe cytotoxicity zeselula.

Ingqalelo bakwazi zinqanda indlela esiqwini ukungavumelani kwaye kuchaphazela phindana omzimba, kodwa kuphela kangangoko encinane isiyobisi. Ethelekiswa "mercaptopurine" iziyobisi esebenzayo liveza ucaca ngakumbi.

iziyobisi Pharmacokinetic

Emva ichiza ngomlomo ako kakuhle iphecana zesisu. It has a iqhina phantsi kunye iiproteni plasma (malunga nama-30%).

Le biotransformation wokukhulula isiyobisi kwenzeka kunye tioinozinovoy acid kunye mercaptopurine (ngamanye amazwi, metabolite esebenzayo). I encinci amayeza kulo kwithishyu. Kulo mzekelo, enamandla encinane beziyobisi afumaneka ebuchotsheni.

Isiqingatha-ubomi azathioprine, kunye metabolites zayo esebenzayo i ngeeyure eziyi-6. Ukufumaneka liphezulu kweziyobisi egazini waphawula emva kwemizuzu 70-110.

Ichiza iyakhutshwa phantse ngokupheleleyo kunye duct, kunye% 1-2 kuphela - ngalo nezintso.

Iimpawu tablets

Ziziphi prescribers "Azathioprine" (imiyalelo ukuba ukusetyenziswa kweziyobisi, analogs, ncomo ziya kuboniswa kamva)? Le ukulungiselela kubonakala kakuhle xa ukungaqheleki zilandelayo:

• ukhwekhwe;
• isifo samathambo;
• elibomvu zomzimba lupus ;
• wenze;
• dermatomyositis;
• myasthenia gravis;
• inhlamba Pemphigus;
• periarteritis nodosa;
• isifo Crohn kaThixo ;
• glomerulonephritis, komzimba;
• hepatitis esebenzayo ezingapheliyo;
• syndrome Reiter kaThixo ;
• purpura thrombocytopenic idiopathic.

Kufuneka kuqatshelwe ukuba eli yeza idla ezimiselweyo nokuthintela yotyando ukulahlwa. Kodwa ke kule meko ayathathwa zidityaniswe kunye namanye amayeza.

Izimo ukuba ukusetyenziswa kweziyobisi

Imiyalelo zokusetyenziswa ichiza "Azathioprine" yazisa izigulane malunga Izimo zilandelayo:

• ukusilela hepatic ;
• hypersensitivity amacandelo esebenzayo okanye abangabancedani amayeza;
• ngexesha lokukhulelwa;
• imeko hematopoiesis abacinezelekileyo;
• yobudala yabantwana;
• ibele.

Medicament "Azathioprine": Izikali kunye nolawulo

Thatha "azathioprine" iipilisi kufuneka kwenziwa ngomlomo kuphela. Kwimeko nganye, le ithamo ichiza uzimisele ngamnye, ngokuxhomekeke ubungqina obukhoyo, kwakunye ubungqongqo sifo kunye nonyango ezihamba.

Kuthintelo amayeza sihlume ukulahlwa emiselweyo nodibaniso 'cyclosporin "kunye corticosteroids. Ekuqaleni ukuthatha unyango amayeza xa kulayishwa ithamo leyo 5 mg kg (ngaphezu ezimbini kweenyanga) nganye. Kamva ukuthatha amayeza e ithamo yesondlo (1-4 mg kg nganye ngeedosi 3). Ngokuqhelekileyo, unyango olunjalo yaqhubeka ixesha elide. Ukuba umisa ithamo therapy amayeza uvikivwa ngokuthe ngcembe.

Xa elivela Iimpawu zokuqala ukulahlwa yelungu zilinywe kufuneka ukwandisa idosi yemihla ngemihla ye medicament kwakhona mg-4 kg nganye.

Kuba unyango nezinye izifo medicament ngesiqhelo yaphathwa idosi yemihla ngemihla 1.5-2 mg kg nganye ku-4 amathamo lahlulwe. Ukuba kuyimfuneko, isixa ezichaziweyo ichiza angandiswa ku 200-250 mg (yahlulwe amathamo 4). Ubude unyango ngale sixhobo ibekwe ngamnye, liyincutshe onamava.

Indlela yokusebenzisa "Azathioprine" (tablets) e isifo samathambo? Imiyalelo yokusebenzisa, ukulinganisa (ukulungiselela ochazwa uchazwe apha ngasentla) ithi ukuba unyango loo kwezifo emiselweyo 1-2.5 mg per kg ngosuku (yahlulwe amathamo 2). Ubude unyango kufuneka iinyanga ezi-3 ubuncinane. Njengokuba ixhasa isigulane inikwa idosi ye 0.5 mg per kg (idosi enye).

Kuba unyango kohlobo B (esebenzayo) amisele idosi yemihla ngemihla 1-1.5 mg kg nganye.

Amacala libanda, iziyobisi

Ziintoni iimpawu libanda zenzeka kwindawo yolwamkelo engalunganga "Azathioprine 'iziyobisi? Imiyalelo yokusebenzisa, oogqirha yokwenene abanamava uxele ukuba idosi aphezulu ichiza kungabangela zikarhulumente ezahlukeneyo dyspeptic, pancytopenia, ukuphazamiseka kwemisebenzi zesibindi nokuphuculwa ezinye iziphumo ebezingalindelekanga ichiza.

Njengoko unyango iziganeko ezinjalo usebenzisa unyango nomqondiso. Ukuba kuyimfuneko, olugqitha esikhumbeni. Nangona kunjalo, qaphela ukuba le nkqubo akuqinisekisi ukupheliswa ngokupheleleyo into esebenzayo emzimbeni.

imithi

Njengabanye iziyobisi kuchaphazela iziyobisi "Azathioprine"? Imiyalelo yokusebenzisa ithi co-zolawulo arhente with "Allopurinol" ngoyo iziphumo zinetyhefu yowokuqala, kwaye ngentsebenziswano "co-trimoxazole" ngokufuthi kukhokelela ngenxa yefuthe myelotoxic.

unyango ngaxeshanye kunye ACE inhibitors kwandisa umngcipheko leukopenia kakhulu.

Xa zidityaniswe namanye immunosuppressants (umz: "Cyclosporins", glucocorticoids, anti-CD3 izilwa) rhoqo ngeendlela ezahlukahlukeneyo neoplasms kunye zosulelo.

ukulungiselela kujongwa liveza isiphumo zingavisisani nedepolyarizuyushim relaxants kwezihlunu.

Kufuneka kuqatshelwe ukuba ugonyo ngexesha unyango "azathioprine" kungaba lula kukhokelela kwezithandani zemveliso omzimba (kwimeko wamachiza inactivated), kwakunye kwandisa phindana wentsholongwane egazini (kunye nokuqaliswa zokugonya njalo).

izincomo ezithile

Izinto ukwazi phambi kokuba ukumisela amayeza "Azathioprine"? Imiyalelo yokusebenzisa, yokwenene (analogue amayeza ezidweliswe ngezantsi) karhulumente ukuba kwiinyanga zokuqala ezimbini unyango kufuneka veki nganye ukuze bagcine indlela igazi yoluvo. Emva kweli xesha, uphando lubonisa amacandelo kunye rhoqo 1 rhoqo ngeentsuku ezingama-30.

Kuyimfuneko ukuba esweni umgangatho yibilirubin, phosphatase obrak kanye enzyme zesibindi.

Phambi ezingaqhelekanga of kwezintso okanye isibindi, kwakunye wondamkela ezimanyene "Allopurinol" idosi medicament phantsi ingqalelo kufuneka kuncitshiswa ukuba yinxalenye 1/4.

"Azathioprine" ngononophelo ngokugqithiseleyo abelwe kwezo izigulane kuye kukho herpes zoster, irhashalala, xanthine oxidase kwale nkqubo, kwaye ngexesha nemitha okanye unyango cytotoxic.

Analogue kunye nexabiso zeziyobisi

Yintoni indawo 'Azathioprine "? Imiyalelo zokusetyenziswa (ixabiso amayeza ezidweliswe ngezantsi) ithi Ndicinga chiza ngoontanga ezimbalwa. Eyona efanayo kakhulu ifuthe ziquka amayeza zilandelayo:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Njengoko ngexabiso, ngoko le mveliso ayikho phezulu kakhulu. tablets 50 "azathioprine" kwi-avareji malunga 230 engange Russian.

Izimvo medicament

A ukubuyekeza ezimbalwa ichiza "Azathioprine" kuthetha mixed. Abanye abantu ngokuthatha amayeza ngenxa isifo samathambo, ngaba wanelisekile ukuvela lwazo ngempumelelo kunye nokungabikho nemiphumela emibi kakhulu. Abanye, Noko ke, izigulane ukuba waziva ngayo nayiphi yoko, ngoko bagqiba ukunika abalukhethayo kwezinye iindlela.

Kufuneka kuqatshelwe ukuba zonke iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi "Azathioprine 'kubhekisela izifo kunokuba kakhulu apho unyango ngokwaneleyo kunokuba abe oqeqeshiweyo nonamava kuphela. Kulo mba, kwimeko rhanelwa phambi nasiphi na isifo ukusuka kuluhlu olungentla, kufuneka bangenele axilongwe ebanzi, kungekhona self-medicate.