Ichiza "Prosulpin": umyalelo manual, imihlolo analogue

Umyalelo "Umyalelo weProsulfin" wokusetyenziswa usetyenziswe njenge-antipsychotic agent, esetyenziswe kunyango lweengxaki ezahlukeneyo zesistim kunye nezinye izifo. Iinkcukacha ezingakumbi malunga neziyobisi zingentla zifundwa.

Inkcazo emfutshane malunga nokulungiselela

Eli liyeza lilo liqela lama benzamines asetshenzisiweyo. Ngenye indlela, kunokuthiwa ukuba izidakamizwa "iProstulfin" yinto efana neuroleptic. Ingxelo yeengcali ibonisa ukuba isenzo sayo sijolise ekunqandeni i-dopamine receptors (i-D2 ne-D3). Siyabulela oku, isilwanyana esingentla singenayo impembelelo ye-antipsychotic.

50 okanye 200 mg yemveliso ye-sulpiride iqulethe enye ipilisi yokulungiselela "Prosulfin".

Kakade ke, kwezinye iimeko, iziphumo ezichaphazelekayo xa uthatha le mayeza zibonakaliswa. Ngako oko, isigulane ngexesha lonyango kunye ne-antipsychotic ngasentla kufuneka libe phantsi kweliso oluqinileyo logqirha.

Eli liyeza linamafomu amaninzi. Itholakala kwifomu yeethebhulethi, kunye nangendlela yeefomsile, isisombululo somjovo we-intramuscular and fluid ukulawulwa komlomo.

Isiza kufuneka sigcinwe kwiqondo lokushisa eliqhelekileyo, kodwa kungabi ngaphezu kwama-25 degrees Celsius. Indawo kufuneka ikhuselwe kakuhle ekukhanyeni nasekunyameni. Phantse kwiminyaka emibini kukuphela komhla wokuphelelwa kwenkqubo "Prosulfin". Iinguqu zokufunda ukufumana oko akunzima. Imarike yezilwanyana inika uluhlu olubanzi lwabafaka endaweni yamachiza angentla apha.

Impembelelo ye-pharmacological ye-arhente engentla yonyango

Isilwanyana "Prosulfin", isithunzi esinikezwe ngezantsi, sisifo sokulwa ne-antipsychotic, oko kukuthi, i-neuroleptic. Inkunkuma ye-sulpiride, ngenxa yokuvalwa kwe-receptors ye-dopamine kwingingqi ye-tuberoinfibdibular, inyuse kakhulu inani leprolactin. Kufuneka kuqatshelwe ukuba kwi-60-80%, iqondo lokuvimbela i-dopamine receptors iyahluka.

Ezi zilandelayo zibonakalisa ukufana okuphezulu kunye ne-benzamide, enesici esichaphazelekayo, njengesiphumo esithintekayo kwinkqubo ye-neurotransmitter dopamine. Ukongezelela, banqanda ukwanda kwe-dopamine kwingingqi ye-synaptic, oko kukuthi, abachasene ne-auto-receptors ze-presynaptic D2 D3.

Kufuneka kuqatshelwe ukuba izidakamizwa zingentla zibonakaliswe ngumsebenzi ohambelana neuroleptic. Olu dlulileyo ludibaniswe ne-timoanaleptic kunye nesenzo esichukumisayo sesi siza.

Isibisi esingentla singenayo isenzo samachiza esilandelayo:

• I-Antiemetic (i-dopamine receptors ikhusele indawo yendawo yokuhlanza);
• Ukuxhatshazwa;
• Antipsychotic.

I-Sulpiride ibonisa umonakalo ochasene nokudityaniswa kwezidakamizwa ukuya kuma-600 mg. Ngaphezulu kweli nqanaba, umphumo we-antipsychotic of this drug on body already already.

Ukongezelela, ukulungiselela "iPsululfin", umyalelo ubonisa oku, uvelisa umphumo okhethiweyo kwi-hypothalamus eneempawu zesilonda se-peptic kunye ne-gastroduodenitis. Ngexesha elifanayo, ukuxhaswa okukhulu kweziko leentlonelo zentsholongwane kugxininiswa, ukunikezelwa kwegazi ngesisu kuphuculwe, ukunyuka kwamathambo e-granulation, iinkqubo zokucima i-muscus kwisisu, ukulungiswa kwe-epithelium kuyenziwa, ukunyuka kwama-capillary kwiishubhu kuphucula.

Ngubani omele athathe la mayeza?

Ziziphi iipilisi ze "Prosulfin" zokubonisa? Ngenjongo yokwelapha iyeza elilapha ngasentla lisetyenziswe kwezi zifo:

• Izifo zengqondo;
• Izilonda zoxinzelelo lwephepha lokutya;
• Izilonda zomzimba;
• Gastroduodenitis;
• Isilonda sesisu;
• I-irritable bowel syndrome (eninzi);
• Izilonda zamachiza;
• I-colontic ulcerative engapheliyo;
• Ukudandatheka kwezi-etymology ezahlukeneyo;
• Neuroses;
• Ukuxinezeleka okusebenzayo;
• Izifo zesifo;
• Schizophrenia;
• Izifo zengqondo ezingapheliyo;
• Migraine;
• Ukuphazamiseka kwengqondo epheleleyo;
• Ukuxakeka kweentlobo ze-etymologies ezahlukeneyo (i-vestibular neuritis, i-vertebrobasilar insufficiency, isifo seMeniere, i- otitis media).

Isilwanyana "Imigaqo yeProsulfin" yokusetyenziswa isichaza ukusetyenziswa ukuphatha ukuphulwa kweendlela zokuziphatha nezengqondo kwizigulane eziselula, oko kukuthi, kubantwana. Ezi zezifo ezifana nokuzilalisa, ukuphazamiseka, ukunyaniseka. Kwakhona, imigaqo ye-"Prosulfin" iyanconywa kakhulu ukuba isebenzise njengenxalenye yecandelo lophiko lobuntwaneni bokuba ngumntwana. Esi sixhobo sisetyenziselwa ukuphatha izigulana ezincinci ezineminyaka engama-6.

Ukungqinelana nokusetyenziswa kweyeza elingentla

Ulungiso "iProstulfin" alukhuthazwa ukuba lusebenze ukuba isigulane sinempawu elandelayo:

• Ukunyanzeliswa kwamanzi kumacandelo eziyobisi;
• Hyperprolactinemia;
• Izifo ezixhomekeke ku-Prolactin (umdlavuza webele, iprolactinoma ye-pituitary gland);
• Izifo ezichaphazelekayo;
• Ubuthi obunxilisayo obunxilisayo;
• Ukuziphatha okubi;
• Pheochromocytoma;
• Ukutyhefuza kakhulu ngamachiza okanye iipilisi zokulala ngamachiza;
• Manic psychosis.

Yonke le miqathango ichanile ngokuchanekileyo. Kwakhona, ukusetyenziswa kweyeza "Prosulfin" akuvunyelwe kubafazi abancancisayo iintsana zabo, abantwana abangaphantsi kweminyaka eyi-18 (iipilisi 200 mg), kwizigulana ezincinane ngaphantsi kweminyaka eyi-6 (iipilisi 50 mg).

Ukongezelela, kufuneka kukhunjulwe ukuba ngokusweleka kokuzalwa kwe-lactose, i-malabsorption ye-gluctose-galactose, ukunyamezela kwe-lactose, akufuneki nokusebenzisa ukulungiselela "iPsululfin". Ukuchasene nokusetyenziswa kweprojekthi yonyango ekhankanywe ngasentla kusebenza nakwabasetyhini abakhulelweyo. Yisebenzise ukuba izigulane ezinjalo zivunyelwe kuphela ukuba inzuzo ekulindelekileyo kule meyile iya kuba phezulu kunokuba ingozi ibe yinto ephuma kuyo ibe yintsana.

Iziphumo eziPhakathi

Xa uthatha isiza "Prosulfin" (umyalelo ubonisa oku), kunokukho iziphumo ezithile:

• Kwinqanaba le-endocrine - i-galactorrhea, i-dysmenorrhea, i-amenorrhea, i-frigidity, i-impotence;
• Ukususela kwicala leentsholongwane, umonakalo, isisu, i-dyskinesia yokuqala, i-extrapyramidal syndrome, ukulala, i-akinesia ene-muscle hypertonia, i-akathisia, injabulo yemoto;
• Ukwandisa umsebenzi we-enzyme (ukusuka kwicala lokutya);
• I-héemolytic anemia, i-leukocytosis, i-anemia ye-anemia, i-granulocytosis, i-thrombocytopenic purpura eyenzeka ngokunyuka kwamaxabiso okulungiselela "iProstulfin" (isenzo kwi-lymph negazi);
• I-Tachycardia, i-orthostatic hypotension, ukunciphisa okanye ukwanda kwimixinzelelo yoxinzelelo, ukuphuculwa kwexesha le-QT, kwezinye iziganeko ukuphuhliswa kwesifo esinobungozi njengokwenzakala kweengongoma (kwintliziyo kunye nenkqubo yakhe).

Ezinye iziphumo ezichaphazelekayo zenza le nyeza. Ukulungiswa kweprosulfin (umyalelo, ukuhlolwa koogqirha kunye nezimpendulo zezigulane zifakazela ngolu hlobo) kunokubangela iziganeko ezinjenge-tardive dyskinesia, ebonakaliswa ngokunyanzeliswa kwesigqibo sokubheka ubuso okanye ulwimi (kunye nehambo eqhubekayo yokwelapha ngama-neuroleptics kuwo onke amaqela), i-hyperthermia. Iingcali ziyalumkisa ukuba kwimeko yokugqibela kubaluleke kakhulu ukuba ukhansele ukulungiswa kwezi ngasentla ngexesha, njengoko ukunyuka kwamaqondo obushushu kungabonakalisa ukuphuhliswa kwesifo esinobungozi njengesihlungu se- neuroleptic syndrome.

Ukunyuka komzimba, ukwanda kwesithuthuthu, ukugqithisa isikhumba kunye nokutshiza - zonke iziphumo zempembelelo nazo zingabangela ukuba iilisi "Prosulfin". Ukufundiswa, iingcebiso zengcali ziphakamisa kwiimeko ezinje ukuyeka ukuthatha iyeza ezilapha ngasentla kwaye uqhagamshelane nogqirha ngokukhawuleza ngoncedo lwezonyango kunye neengcebiso.

Sebenzisa ngexesha lokukhulelwa komkhiqizo olapha ngasentla

Isiphumo se-tatogenic ye- chiza ayifumanwanga ngenxa yesilingo sezilwanyana. Abanye abafazi abasebenzisa eli gama ngexesha lokukhulelwa kwabo abazange bagcine umphumo ongentla. Kodwa ezi gulane zithatha iqondo elingaphantsi kwe "Prosulfin". Imiyalelo yokusetyenziswa, ingxelo yeengcali ayinalo ulwazi oluthe ngqo malunga nokusetyenziswa kwexabiso eliphezulu lezinto ezifana ne-sulpiride. Akukho bukho ubungqina befuthe lesilwanyana esingentla apha ngentuthuko yengqondo yomntwana.

Njengengqinisiso yokuqapha, iingcali azicebisi ukusebenzisa eli liyeza kubasetyhini kwimeko. Nangona kwezinye iimeko, unyango olunezi zilapha ngasentla luyamkeleka kwizigulane, elindeleke kulutsha, kodwa ngokuthe ngqo kwiiyithithi ezincinci.

Iingcali ziqaphele ukuba ukuba unina ufumene unyango ngama-neuroleptics ixesha elide, izicucu ze-neonatal ziye zineengxaki ekusebenzeni kwendlela yokugaya (umzekelo, ukucima.).

Ukuba ibhinqa isebenzisa iyeza kwixesha ngaphambi kokubeleka, ke ukulawula umzimba wakhe nokuphuhliswa komntwana ngokugqithisa ugqirha.

Kwakhona, khumbula ukuba isilwanyana "iProstulfin" singene ebisi lwebele. Imiyalelo yokusetyenziswa, uphononongo lwengcali alucebisi ukuba uthathe ngexesha lokutya.

Indlela yokuthatha isilwanyana "Prosulfin"?

Uqeqesho luyalela izigulane ukuba zisebenzise i-antipsychotic ngenhla nganye iiyure eziyi-8 kwipilisi enye. Akukhuthazwa ukuthatha iyeza emva kwe-4 ntambama, njengoko umsebenzi walo ngeli xesha liphezulu kakhulu. Kufuneka kuqatshelwe ukuba isetyenziswe kungakhathaliseki ukungena kokutya kwaye ihlanjwe ngexabiso elaneleyo lokulungiselelwa kwamanzi "Prosulfin".

Iibhilethi eziqulethe i-200 mg ye-sulpiride zithathwa ngeempawu zesifo se-schizophrenia, isifo sengqondo esisondezayo kunye nokuxinezeleka. Isiza linga kuthathwa ngeendlela ezininzi. Umthamo omkhulu wemihla ngemihla ngowama-100 mg, oko kukuthi, malunga neepilisi ezi-5.

Iibhilethi, eziquka 50 mg ye-sulpiride, umyalelo ubonisa ukuthatha ukuba isigulane sibonisa iimpawu ze-neurosis, ixhala. Kwiiveki ezi-4, izigulane ezinjalo kufuneka zidle ubuncinane kunye neepilisi ezi-3 ngosuku.

Kwakhona, iipilisi ezinjalo zingathathwa kubantwana abanezifo ezinzima zokuziphatha. Ubudala bezo zigulane kufuneka kube ngaphezu kweminyaka engama-6. Umthamo wemihla ngemihla yezigulane kule nqanaba uvela kwi-5 ukuya kwi-10 mg nge-10 kg yesisindo somzimba womntwana.

Ukugqithisa

Umyalelo ubonisa ukuba ulwazi malunga nokugqithisa kwe-sulpiride lucacisiwe. Ezi zimpawu zilandelayo ziyakubonwa kule mqathango kwisigulane:

• Ukukhuselwa kolwimi;
• I-Dyskinesia ene-spasmodic torticollis;
• Umbono ogqityiweyo;
• Umlomo omile;
• Mhlawumbi uphuhliso lwe-NSA;
• Izimpawu ze-Extrapyramidal;
• Ukwandisa ukujuluka;
• I sihlunu;
• Impembelelo yokwehlisa;
• Gynecomastia;
• Parkinsonism;
• Ukunyuswa kwengcinezelo.

Ukunyangwa kwimeko engentla yesigulane kwenziwa ngolu hlobo lulandelayo:

• Isisu sesigulane sihlamba;
• Ukunikezelwa kwekhabhoni esebenzayo;
• Ukusetyenziswa kwonyango.

Ukuba kunyanzelekile, kwiimeko ezinzima kakhulu, ugqirha unokuyalela ezinye iindlela zokunyusa, ezifana ne-diuresis yokunyanzeliswa kunye ne-infusion ye-alkaline izisombululo okanye ukubeka esweni imisebenzi ebalulekileyo yomzimba.

Kufuneka kuphawulwe ukuba le nkunkuma inokwenziwa ngokukhawuleza ngexesha le-hemodialysis.

Ezinye iindidi zezigulane kufuneka zithathe amanyathelo okuqaphela xa usebenzisa i-drug "Prosulfin". Oku kusebenza ngokukodwa kubasetyhini abanexeshana, ukuya kwizigulane ezinexinzelelo ezinzulu kunye nomfutho wegazi ophezulu.

Kwakhona kubalulekile ukuqhuba uviwo lokuqala lwe-electrophysiological kunye neklinikhi kwizigulane ezinokuhluthwa. Kufuneka kukhunjulwe ukuba ukulungiselela "iProstulfin" kunciphisa umda wokusebenza ngokuxubha.

Ukongeza, xa uqhuba iimoto kufuneka uqaphele kakhulu ngexesha lonyango kunye neyeza eli ngasentla. Kwakhona kubalulekile ukunciphisa imisebenzi efuna ukusabela ngokukhawuleza kwengqondo kunye nokunyuswa kwengqalelo.

Ukusebenzisana namanye amayeza

Umyalelo ngokuthe ngqo awucebisi ukufakwa kwesi sidakamizwa esingentla apha kwiinkqubo ezinonophelo zonyango nge-levodopa. Ezi zinto zimbini zisebenzayo ziyi-antagonists. Ukuba isigulane esinezifo ze-Parkinson sithatha i-levodopa, ngoko ugqirha kufuneka akhethe i-remedy enefuthe elincinci le-extrapyramidal.

IArrhythmia efana ne-torsades of pointes inokubangela inhlanganisela yokulungiselela "Prosulfin" nge:

• Izidakamizwa ze-Antiarrhythm eziklasini Ia (iziyobisi "Dizopiramid", "Quinidine");
• Ukulungiselela iPimozid, Haloperidol, Thioridazine, iCisapride, i-Pentamidine, i-imipramine i-anti-depressants;
• Izidakamizwa ze-antiarrhymic ezibandakanyiweyo kwiklasi yesithathu (iSotalol, Kakamiodaron);
• Iziyobisi ezibangelwa iimpawu zesifo ezifana ne-bradycardia (i-beta-blockers ye-calcium);
• Iziyobisi ezifaka isandla kwimbonakalo ye-hypokalemia (i-laxatives evuselela, i-hypokalemic diuretics, i-tetracosactides, i-glucocorticoids);
• Abaphikisi be-Antiparkinsonian: i-apomorphine, i-amantadine, i-lisurid, i-ropinirole, i-entacapone, i-bromocriptine, i-selegiline, i-pramipexole, i-piribedil);
• I-neuroleptics, enekhono lokubangela iimpawu ze-pirouette tachycardia (i-Chlorpromazine, i-Amisulpride, i-Tsiammamizin, iPimozid, i-Droperidol, i-Levomepromazin, i-Tiaprid, iSertindol, i-Veralipride, i-Sulpiride). ;
• Iziyobisi eziqukethe i-lithium (ekugqibeleni ukunyusa ingozi ye-extrapyramidal disorders).

Kwakhona, akukho naluphi na uhlobo kufuneka ukulungiselela "iPsululfin" kutywala ngotywala. Olu hlobo luyakubangela ukuba umonakalo owenzayo wokuba neuroleptics.

Ukongeza, ukuba uthatha le nyeza apha ngentla kunye nezinto ezishukumisayo (i-antiasthmatic drugs, anorectics), ngoko isigulane sinokubonakalisa iimpawu ezinzima zokukhathazeka, ukwesaba, ukuxhalabisa, ukuxhalabisa.

Kufuneka kukhunjulwe ukuba le nkunkuma ye-antipsychotic inciphisa izinga lokuphumelela kwe-ropinirole.

Amagqabi e-arhente yokwelapha "Prosulfin"

Izidakamizwa zesicatshulwa esingasentla se-antipsychotic:

• "Betamak T100";
• "Vero-Sulpirid";
• "Betamax T50";
• "Khuphela";
• "Betamax";
• "Dogmatist";
• "Betamaks T200";
• "Sulpiride";
• "Egonil";
• "Sulpiril";
• "Eglek".

Kodwa ukutshintsha ngaphandle kokubonisana kwangaphambili nogqirha akacebisi ukuba "i-Prosulfin" imiyalelo yokusetyenziswa. Izalathisi zakhe nazo zinemiphumo yazo. Bangabangela ingozi enkulu kwimpilo yesigulane.

Iimpendulo kwisixhobo sonyango "Prosulfin"

Uphononongo malunga neli phepha ngasentla lihle kakhulu. Zininzi izigulane zithatha xa zixinezelekile. Bathetha ukuba le mpendulo inceda ekupheliseni iimpawu zesi sifo ngo-100%.

Ngaphezu koko, izigulane ezininzi iimpendulo ezaneleyo, nto leyo izifo ezifana schizophrenia, enterocolitis, ukudumba, ukugula ngengqondo, enteritis, isifo sisilonda, udikwa ngokukhawuleza kwesisu syndrome, wathabatha ichiza "Prosulpin". Izimvo ibonisa ukuba kuzo zonke iimeko, isixhobo ivelise isiphumo ukuphiliswa engakholelekiyo. Ukongeza, izigulane ingxelo ukuba kukho iziphumo ezingalindelekanga kunqabile kakhulu.

Ichiza ngasentla lineziphumo ebezingalindelekanga ezimandundu, ngoko sebenzisa ngaphandle ngokudlana iindlebe ugqirha akuvumelekanga ngokungqongqo.