Drug "Arlette": imiyalelo ukusetyenziswa, Izimo, ukwakhiwa kunye nohlolo

Xa kuphuhliso penicillin elula yaba ilikhubalo lokunyanga kwezifo eziliqela iintsholongwane abantu kwiimeko ezininzi wafa. Ukususela ngoko, abantu zagqobhoza ngaphaya kwenye nkulungwane, kwaye sele livelise iqela zonyango amachiza antibacterial njenge olubanzi-spectrum, kwaye bayaziva naluphi na uhlobo lwe silwanyana. Enye ezinjalo isixhobo i "Arlette". ekusetyenzisweni kwesi sikhokelo iyeza iqulathe ulwazi olubanzi malunga zonke iipropati yayo.

Ukubunjwa arhente antibacterial

Awona macandelo aphambili ke trihydrate amoxycillin (kubalwa njengokuba amoxicillin imiqulu 250, 500, 875 mg kunokwenzeka) kwaye potassium clavulanate (umthamo - 125 mg, ngokusekelwe clavulanic acid). Icandelo lokuqala ibizwa ngokuba uthotho penicillin semisynthetic, ebonakala ngu intsimi ebanzi yomsebenzi antibacterial. Icandelo lesibini ezinkulu medicament yi ngumqobo lakho beta-lactamases.

Ukongeza, iqela yeekhomponenti abancedisayo besekhaya iyeza "Arlette". Imiyalelo zokusetyenziswa, inkcazo yokulungiselela kuthathelwa ingqalelo yabathengi anokufumaneka ekwakhiweni elisezantsi beemolekyuli engundoqo ubunzima povidone, starch pregelatinized, calcium stearate, microcrystalline neselulosi kunye talc. Kwaye loo nto bonke.

Le istili kwakheka zintsholongwane hypromellose, propileglikol kunye polyethylene ethers 4000 (macrogol okanye 4000), titanium dioxide. Ubunzima audio «Arlette" iipilisi (yemiyalezo liqulathe ulwazi) 600, 1100 okanye 1600 mg.

pharmacodynamics

Njengoko kuchaziwe ngaphambili, "Arlette" yinto entsokothileyo amoxicillin kunye clavulanic acid. Iifom ikamva isakhiwo esitalini inactivated kunye beta-lactamases (enzayim iintsholongwane msebenzi ungundoqo esakhiwa ngo ekulweni antibiotics beta-lactam, zezona lwimi kusetyenziswa elwa Chemotherapy - cephalosporin, penicillin, njl ...). Beta-lactamases banoxanduva nokudalwa inkcaso ezingisayo ukuya izixhobo zonyango ukhankanywe ngentla.

Ngokwawo, clavulanic acid, ogama isakhiwo iyafana naleyo iziyobisi beta-lactam, iphawulwa ubuchule kunokuba buthathaka antibacterial yakhe. Kunjalo, ubukho acid kwi "Arlette" kuqulunqo amoxycillin uyabachasa Imbuqo kwandisa indawo amathuba ayo antibacterial, kuquka kulo iintsholongwane microorganisms abanganyangekiyo eqhelekileyo iimeko impembelelo amoxycillin, ezinye esebenzisa amaqela penicillins kunye cephalosporins.

Zintsholongwane "Arlette" imiyalelo zokusetyenziswa njenge medicament silawula indawo exposure ebanzi. Yena esebenzayo nxamnye basengozini Ngeentlobo amoxicillin (hayi ngaphandle kwaleyo nokulungelelanisa beta-lactamase). Ezi ziquka uluhlu iintsholongwane gram-HIV kunye gram-elibi aerobic kunye anaerobic.

Iimpawu "Arlette" lithetha

ukusebenza Field kwi -arhente antibacterial kunokuba enkulu, ukuba iyasebenza eziliqela etymology ezahlukeneyo. "Arlette" imiyalelo mvume zokusebenzisa ukusebenzisa ukusombulula iingxaki iphecana ephezulu bokuphefumla phecana eliphezulu zemiphunga. Ingakumbi sithetha ngayo iifom oyingozi futhi okondeleyo sinusitis kunye otitis eendaba, a tonsils, pharyngitis, amathumba kwindawo retropharyngeal. Igalelo elihle a medicament kuba unyango lwe izifo inkqubo esezantsi nokuphefumla, eziquka iphika (ezingapheliyo kunye etsolo, ekhatshwa superinfection bacteria) kunye nenyumoniya.

Nangona kunjalo, akukho zonke iindawo apho Arlet isicelo. Imiyalelo yokusebenzisa, iyeza inkcazelo ziye ingxelo ngempumelelo yalo unyango lwezifo kwenkqubo genitourinary kunye amalungu zangasese. izifo ezifana ziquka pyelonephritis, prostatitis, urethritis, endometritis kunye හසුරුව isiphathi yebhaktiriya, ukuqhomfa yokubolisa, ukuvuza ngaphantsi kunye m. P.

Kwakhona ngokuqinisekileyo iphembelela zintsholongwane kwi ukunyanga ulusu kunye kwizihlunu ezithambileyo izifo oluphuma kwiindawo ezahlukeneyo (mathumba, cellulitis, erysipelas, impetigo, umphezulu enxebeni kwakhona abosulelwe usulelo dermatoses). "Arlette" ungasetyenziswa ukunyanga ngethambo kunye nokuqina zomzimba, biliary prolechivanii iphecana (cholecystitis, cholangitis), e izilonda odontogenic, lokuthintela iinkqubo ukudumba kutyando, ngamaxesha postoperative.

Umthamo kunye neendlela isicelo

Kuba iziyobisi "Arlette 'indlela yokusebenzisa kunye nedosi azimisele ngamnye kwaye kuxhomekeke kubudala, ubunzima, imeko izintso nobukhali usulelo. Ukwenzela ukunciphisa amathuba neziphumo ezibi iphecana zesisu, cwecwe kufuneka athathwe phambi kokuba wokudla, njengoko iyonke, musa ukuhlafuna asele namanzi.

Izigulane ngaphezu kweminyaka eyi-12 ubudala okanye ubunzima bomzimba-40 kg nokukhanya ngeenjongo zokumodareyitha iifom izifo athathe ipilisi enye (250 mg becandelo eziphambili) kathathu ngemini okanye kabini ngosuku (500 mg amoxycillin). Kakubi kakhulu athathe idosi elilingana 500 mg amoxicillin izihlandlo ezithathu imihla okanye 875 mg - kabini emini.

Izigulane kweminyaka 6 ukuya ku-12 "Arlette" yemiyalezo icebisa, ngokusekelwe ubunzima 1 kg amoxycillin - 20-30 mg Clavulanic acid - 5-7.5 mg. Ngokubanzi, ithamo kwezi zigulane yi-1 tablet (250 mg) kabini okanye kathathu ngemini okanye icwecwe-1 (500 mg) kabini yonke imihla. Kwiimeko kakhulu, ukuze liphindwe idosi.

Izigulana umsebenzi kidney kakuhle idosi nomthamo frequency luhlengahlengiswe kuxhomekeke zesigunyaziso creatinine. Abo abaphethwe anuria, ekhefu phakathi izidlo kufuneka lenyuke iiyure 48 okanye ngaphezulu. Kuba izigulane ihaemodialysis, isixa medicament okhethiweyo ukusuka idosi ubuninzi amoxycillin.

Abantu abakhubazekileyo nokusebenza kwesibindi ngobunono unyango iziyobisi "Arlette". Imiyalelo yokusebenzisa (abstract), uhlaziyo iingcali zonyango kucetyiswa ukuba gqolo esweni imeko umzimba.

Izigulane abadala kufuneka uhlengahlengiso idosi.

imiphumela emibi

uluhlu oluthile yeziphumo ebezingalindelekanga iquka zintsholongwane for "Arlette" umyalelo manual. Unyango (nomonde ingxelo zaqinisekisa) esi sixhobo kungabangela eziliqela ukutenxa kule iphecana zesisu ngokohlobo ukungabi namdla, isicaphucaphu, ukugabha, urhudo. Maxa wambi uyakwazi ukuva isibindi kwabantu, kodwa ubuncinane - ekuphuhliseni senyongo cholestatic, hepatitis, wenze pseudomembranous.

Indlela yenkqubo luvo yokusetyenziswa "Arlette" iziyobisi ibe nentloko ebuhlungu kunye nesiyezi, ukungahlaliseki (ngokohlobo ingathityazwa) kunye nomsebenzi nokuhlutha.

inkqubo Hematopoietic zinako ukuphendula ukuvela kweempawu leukopenia of igazi hemolytic, agranulocytosis. Mhlawumbi ukwandisa ixesha prothrombin (kulo mzekelo, le nkqubo ingathityazwa). Crystalluria kunye nephritis Embi - imiphumo ichiza ukusuka kwinkqubo womchamo kunokwenzeka.

uluhlu ngokubanzi ngokwaneleyo yokusabela kunokwenzeka bagulayo olwa "Arlette". Imiyalelo, inkcazo ichiza ulwazi kubathengi malunga nophuhliso pruritus, urticaria, amaqhakuvana erythematous kunokwenzeka. Maxa wambi uyakwazi ukuva iimpawu multiforme erythema exudative, angioedema, ukothuka anaphylactic. Kukho ulwazi malunga wabonakala ngamnye yeziphumo ebezingalindelekanga ngohlobo Stevens-Johnson syndrome, kunye dermatitis exfoliative.

Izimo ekusebenziseni "Arlette"

Uluhlu izizathu ezikwenza ukusetyenziswa-ntsholongwane, kuba medicament iquka "Arlette" umyalelo manual. Izimo ukunciphisa ukuphathwa kwabo nezigulane ezehlelwa hypersensitivity ngamnye ukuya amacandelo aphambili kunye nkampani ichiza kwezinye iiarhente beta-lactam antibacterial (penicillins, cephalosporins kunye ezifana. P.). Not wabelwa "Arlette" kunye nabo babe imbali yokurekhoda ukusebenza Kakubi Kweziyobisi unyango kwesibindi amoxicillin kunye clavulanic acid kwi entsonkothileyo. Imithi contraindicated abo ukubandezeleka mononucleosis kunye lymphocytic wegazi, njengoko lwandisa amathuba yokuvela exanthema.

Izizathu zokwala unyango ngale zintsholongwane kukho ukusilela ezingapheliyo kwezintso kunye nabantwana ukuya kwiminyaka emi-6.

Ke bona abafazi abakhulelweyo, ukuze bathathe "Arlette" kuphela xa izibonelelo unina obungathandabuzekiyo mkhulu umngcipheko waqonda olungekazalwa. Xa zisanyisa iinkalo eziphambili beziyobisi ngezixa ezincinane ngobisi, ngoko umele uxoxe nogqirha wakho umbuzo nokwala ukuncancisa.

ngeedosi kakhulu

Ukuphazamiseka ye wokugaya - elo qela engundoqo iimpawu uphawu libanda, iziyobisi, "Arlette" (tablet). Imiyalelo yokusebenzisa, angqina nomonde ziye ingxelo ukugabha, urhudo, iintlungu esiswini. Ngaphezu koko, kusenokuba kukho iimeko ezifana ubuthongo, kunye nesiyezi, ukuphazamiseka. Kunqabile ukuva nokuxutha izinto.

Xa iimpawu libanda, i isisombululo kangangoko ukuba nomonde - kuba phantsi kweliso yincutshe. Unyango Kwiimeko ezinjalo nomqondiso.

Ukuba into yokufumana ithamo inkulu ngokungamkelekanga, kwakukho iiyure kungekho ngaphezulu kwe-4 eyadlulayo, kuyimfuneko ukuba iphume esiswini uthabathe iziyobisi, adsorbents (ezifana ngamalahle yasebenza) ukwenzela ukunciphisa ukufunxeka. Kuba ukususwa kulo mzimba amoxicillin kwaye clavulanic asidi ihaemodialysis olusebenzayo.

Intsebenziswano kunye nezinye izinto kunye namayeza

Xa yokwamkelwa ukufana "Arleta" yaye "methotrexate" uya kwandisa ubuthi wamva. Ngokuphawulekayo sinciphile kwaye bacothe kukufakwa le asidi zonyango, glucosamine, aminoglycosides. Ascorbic acid, phezu koko, ukunyusa ukufakwa - olo lwazi uquka zintsholongwane "Arlette" umyalelo manual.

Ixabiso iyeza kuyahlukana nedlela oyidlayo kunye mmandla, kodwa zikhona kuluhlu olubanzi kwabathengi. Ngoko kuyimfuneko ukuba udibane nogqirha wakho, uze musa lakhe ukudibanisa nokusebenzisa imithi kunye nezinye iziyobisi.

"Arlette" coagulants ngenxa inhibition le microflora wamathumbu isiphumo proximity, ukunciphisa imveliso vitamin K kunye nokuncitshiswa index prothrombin. Xa ukwamkelwa ngaxeshanye kunye neziyobisi, anticoagulants kubalulekile ukuba bathi gqolo ekubekeni iliso yoMgaqo igazi ekunqandeni. ukusebenza Ukuncipha zokucwangcisa ngomlomo.

NSAIDs, womchamo kunye namanye amalungiselelo zonyango abathintela secretion tubular, nande egazini uyazikhomba amoxicillin.

Tandem "Arlette" ne "Allopurinom" kunokubangela uphuhliso exanthema. antibiotics Bactericidal kukhokelela synergism kunye neziyobisi kunye indlela bacteriostatic unempembelelo - to awunandaba.

imiyalelo Special

Ngenxa yokuba iziyobisi "Arlette" (umyalelo manual iqulathe ulwazi) kunye ngeedosi ezahlukeneyo amoxycillin ziquka, Noko ke, umlinganiselo ofanayo clavulanic acid (125 mg) kufuneka kukhunjulwe ukuba amacwecwe amabini ka-250 mg amoxicillin Akunguye nakanye kuthetha okulingana elinye icwecwe 500 mg ukwimo.

Kufuneka kwakhona kukhunjulwa ukuba izixa ezikhulu amoxicillin ukukhala impendulo okungamanga xa kujongwa inqanaba glucose Umchamo xa esetyenziselwa izixhobo uhlalutyo, ezifana Benedict kaThixo reagent okanye isisombululo ewisa. Kungcono kwiimeko ezinjalo ukusebenzisa reactions enzymatic ne glucosidase.

Xa isicelo amazinga zintsholongwane eziyimfuneko ukuze esweni rhoqo imeko imisebenzi igazi, kwesibindi kunye nezintso. "Arlette" kwiimali ekucetyiswa aluchaphazeli ukukwazi ukulawula nokwenza imisebenzi yendlela ezifuna ingqalelo nesantya eliphezulu ngayo lengqondo.

Ixabiso Range kunye noluvo kwabathengi malunga ichiza

Ulwazi malunga iidosi yeekhomponenti ezingundoqo kwi lweziyobisi olunokubakho iqulethe for "Arlette" (icwecwe) imiyalelo ukusetyenziswa. Price, njengoko kuchaziwe ngaphambili, oku kuxhomekeka idosi kummandla apho medicament leyo okusebenza. Umzekelo, amacwecwe bhanya kugalelwe kwi ithamo 875 mg + 125 mg eMoscow zingathengwa ukuba imali kuluhlu ukusuka engange-270 ukuya 310 (iziqwenga 14 pack nganye). E St. Petersburg iphakheji efanayo liya kuxabisa 278-282 engange.

Ngokumalunga iimbono izigulane malunga mveliso amayeza oko kukuthi feedback ebezintle nezo zingentle malunga ichiza. Iqela elikhulu zezigulane kubonisa ukusebenza ezigqwesileyo unyango lwezifo Kwiphecana eliphezulu bokuphefumla phecana eliphezulu zemiphunga. Amayeza ngokukhawuleza nangempumelelo ukumelana sinusitis, kunye noxolelo lide ngokwaneleyo ngoko. impumelelo yalo unyango lwezifo iintsholongwane nazo kungqinwe izigulane ngokutsha.

ukubuyekeza ezimbi ngale mveliso amayeza "Arlette" bavame ngenxa yobukho kubaguli hypersensitive amacandelo zeziyobisi. Kwiimeko ezinjalo, abantu basoloko bethetha ezinxaxhileyo ekusebenzeni phecana wokudla, ezifana: ukungacoleki kokutya, isicaphucaphu nokugabha, urhudo. Malunga na engaqhelekanga kakhulu ngakumbi phantse akukho lwazi.

Nakuba kunjalo, kufuneka wathi ukuba le arhente antibacterial iye lityunjwe gqirha khona kwaye wathatha kwakhona i amachiza, iintlobo ezahlukeneyo zokutenxa ezingalindelekanga kunqabile kakhulu. Ukuba into efana naleyo Bekusithi, ugqirha aya kuyinyula efanayo impembelelo kunye nocikizeko yinzuzo analog kwemarike zoxubo Russian Igcwele antibiotics kunye spectrum ezibanzi amanyathelo.