"Disulfiram": ncomo. "Disulfiram": incazelo, ixabiso

Kweli nqaku, siye sagqiba ekubeni ndithi kuni le neziyobisi "Disulfiram". Imiyalelo ukusetyenziswa, impendulo ezibonisa imali liya kuchazwe ngezantsi. Ukongeza, uya kufunda ukuba yintoni na iindleko amayeza wathi, oveliswa kulo naluphi na uhlobo esele ifakiwe kumafa yawo, njalo-njalo. D.

Ifomu kunye nokwakheka zizinto ebekupakishwe

Le medicament "Disulfiram", imiyalelo zokusetyenziswa leyo livalelwe kwibhokisi eyenziwe yekhadibhodi, le ithunyelwa ngokohlobo isisombululo olunamafutha kunye neepilisi ze nolawulo yomlomo umzila.

Ifomu yokuqala evela nengqayi ye ml-20, kwaye eyesibini neyesithathu - sinayo iglasi kwiiyunithi-10 no-20 ngokulandelelanayo.

Eyona nto elikhutheleyo medicament yi disulfiram. Ngaphandle kwalo, ichiza iqulethe kwakhona amacandelo ezongezelelweyo (kuxhomekeke iifom ukukhululwa): chloride sodium, mannitol, starch, isodiyam stearate, peg-6000, MCC, calcium diphosphate, neselulosi hydroxypropyl, stearic acid kunye polyoxyl 40.

iipropati kwemithi

Yintoni na phambi kwethu amayeza? Oko bathi ngaye ukubuyekeza zonyango? "Disulfiram" kunempembelelo anti-utywala ngokukhawuleza.

Xa ufumana le sixhobo elaziwa impembelelo yayo obonakalayo ukutya utywala. Ngenxa yoko, metabolites ekhuselekileyo bayazibhijabhija, leyo ukwandisa lwee- izinto eziyityhefu ezifana acetaldehyde. Yaba nguye lowo kugqiba ukusebenza beziyobisi.

Kunye nolawulo emthanjeni xa medicament, ngokunjalo izigulane zawo ngomlomo phantse nangoko uqale ukuba ukufikelwa, ukuqunjelwa etsolo, tachycardia, asthenia esomeleleyo hypotension nokuba lisibekele. Ukongeza, ukubonakala ukunxila ngu acetaldehyde negalelo Ukwehluleka utywala kunye nokupheliswa yasolula isigulana utywala.

pharmacokinetic iparameters

Yiyiphi ingcamango na ichiza kinetic iparameters? Kuthekani nophononongo ingxelo Ukunciphisa? "Disulfiram" ugxile kakhulu ngokukhawuleza kwaye phantse ngokupheleleyo ethunjini.

Xa usebenzisa oko, kukho ukutya eliphezulu candelo esebenzayo, apho kwasekwa metabolites eziliqela. Ukuveliswa imveliso lwenziwa nge emiphungeni kunye nezintso.

Ubungqina obubonakalayo buxela

"Disulfiram" iziyobisi, ixabiso yayo eboniswe ngezantsi, kuboniswe ukuba:

• unyango butywala ezingapheliyo;
• uthintelo kokuwela kwi ukunyanga butywala ezigulo ezondeleyo.

Thatha le iyeza ngokokubona kwayo ezingafunekiyo. Kufuneka lityumbe ugqirha.

Izimo

"Disulfiram" Drug butofelwe kwaye ngomlomo akukhuthazwa ukuba ezi zifo zilandelayo:

• izifo neuropsychiatric;
• sokuwa;
• seswekile.

Kwakhona, le ichiza akayibonisanga ngexesha lokukhulelwa, uvakalelo icandelo esebenzayo kunye njengesakhi ezongezelelweyo, nokuncancisa.

Kufuneka kwakhona uqaphele ukuba ngononophelo kakhulu eli chiza Kucetyiswa ukuba ungenisa izigulane umsebenzi kwesibindi kakuhle, isixokelelwano sokuphefumla kunye nezintso.

Drug "Disulfiram": imiyalelo yokusebenzisa

Ukusetyenziswa naluphi na uhlobo lwe-mali wamahashe kuphela odolo zikagqirha. Ugqirha unyanzelekile ukuba kuqhuba uviwo olupheleleyo yomguli, uze ukhethe irejimeni yonyango ngamnye uwadle ngaye.

Ngokutsho imiyalelo, umlinganiselo idosi yemihla ngemihla ichiza ukuze kulawulo yomlomo imalunga 125-500 mg.

Ke ukuba kutyalwe kunye umzila beziyobisi, ngoko ezi nkqubo kufuneka kwenziwa lweengcali onamava. Kulo mzekelo idosi abawacebisayo ichiza kuxhomekeke iimpawu kumguli nobukhali izifo ezikhoyo.

imiphumela emibi

iziphumo ebezingalindelekanga beziyobisi umbuzo ndibizayo? Kuthekani oku bathi nokubuyekezwa? "Disulfiram" kunqabile ukuba babe imbangela ngayo ebezingalindelekanga eziyingozi. Xa tapeworm kusenokuba kukho umahluko wokugaya kunye nobukho incasa sisinyithi kunye nophuhliso kwesibindi.

Ukongeza, ukunyhashwa angenzeka imisebenzi luvo. Iimeko ezinjalo engathandekiyo ziquka polyneuritis of nemilenze, ukuphazamiseka kwengqondo, ukulahlekelwa inkumbulo, nokudideka kunye intloko ebuhlungu.

Kwakhona, musa ecaleni uphuhliso reactions ezahlukeneyo kukwalisa, leyo kuxhokonxwa kweempembelelo zotywala (umz, ukuwa, ukufa kwamalungu omzimba, arrhythmias kwentliziyo, nokudumba ebuchotsheni kunye iposi engabalulekanga).

Iimpawu libanda

Ukulungiselela "Disulfiram" xa amathamo aphezulu kunokubangela iziphumo ezifana ukuwa, isiqaqa kunye nezenzo eziyingozi luvo.

Ukuphelisa ezi mpawu kufuneka achithe unyango kwangumqondiso esibhedlele, kufuneka ukuba sibandakanye imisebenzi ubuthi.

Antidotes medicament

Iingcali ziye zabonisa ukuba neutralization epheleleyo ichiza ayikwazi kuqwalaselwa.

Ukuba kuyimfuneko, imveliso "Disulfiram" emzimbeni womntu (ithamo umz, xa iintshukumo eziqatha ezisanda yamkelwa zotywala) kukho iinkqubo ezithile wenziwe.

Njengoko alikaziwa kule ukusetyenziswa kweziyobisi ascorbic acid. It iphethwe yegazi. Le element akavumi ukuba utywala ukuba uguqulwe acetaldehyde, leyo, enyanisweni, ebangela ubuhlungu.

Kwakhona ephedrine ezisetyenzisiweyo kunye H1-blocker.

imithi

Ingaba kulungile ukusebenzisa ezinye iziyobisi phambi kwethu amayeza? Kuthekani imithi reviews bathi? "Disulfiram" kunye anticoagulants kwandisa isenzo sabo, yaye kwandisa ingozi ukopha.

unyango ngaxeshanye kunye amayeza lweziyobisi umzimba esibindini, uyakwazi kwehlisa kakhulu ngexesha lenkqubo.

Ukudibanisa Mao inhibitors, lakhula tricyclic nezakhi phenothiazine with "Disulfiram 'inokuba negalelo ukuvela reactions icala ezintsonkothileyo.

Indibaniso oku kuthetha with "buspirone" ebangela uphuhliso iimfeketho zokufeketha. Ezifana amayeza njengoko "Amitriptyline", ngokufuthi iphucula isiphumo 'Disulfiram "kwaye uphakamisa neziphumo zayo yityhefu kwi-luvo.

Kujongwa ikwazi medicament yokwandisa yoxinaniso of chlordiazepoxide kunye diazepam egazini, ukunciphisa amandla reactions eziyityhefu nokunqanda nesiyezi.

Kunye indibanisela 'Disulfiram "ne" isoniazid' ukuze aphuhlise ukudandatheka kunye nesiyezi, "metronidazole" - ukudideka kunye ngengqondo ebukhali, i "Omeprazole" - kakuhle zingqondo, kunye caffeine - kuncitshiswa zinomgutyulo wayo emzimbeni.

"Chlorzoxazone" kwandisa uyazikhomba nechiza elichasene-utywala egazini, yaye "Chlorpromazine" inyusa hypotension.

Drug "Disulfiram": ncomo, ixabiso kunye analogue

neziphumo ezifanayo ziye iziyobisi ezifana "Ekzorran", "Radotera", "Aspen", "Krotenal", "Tetlong", "Refuzal", "Stoptil", "Antietil", "Kontrapot", "Tetradin", "Antietan" "Dizetil", "Alkofobin", "Aversan", "Anticoli", "Antabuse", "Esperal", "Lidevin", "Abstinil".

Yimalini iziyobisi 'Disulfiram "? Ixabiso eli chiza emacwecweni Umfuno engange 200-1000 (ngokuxhomekeke umenzi). Ngokumalunga ukumila koko iye, kwakunye sisombululo olunamafutha, ukuba kuthengelwa 600-2400 engange.

reviews Inkoliso kuqulunqo lakalokunje HIV. Kuyaphawuleka ukuba eli chiza isoloko isetyenziswa unyango ofihlakeleyo abantu butywala. Iingcali azilukhuthazi ukupha eli ziko ngaphandle kolwazi yesigulane.

Ngokutsho ingxelo abo basebenzisa iziyobisi kuqwalaselwa ngokuphumelelayo kakhulu ilwa siyanibongoza ukuba athathe idosi entsha utywala. Ngokuqhelekileyo, emva kokufumana ichiza kwi isigulane kuvela Ukwehluleka utywala. Ukuba utywala ligqithise emva ngokusebenzisa ichiza, yenza ukuqunjelwa etsolo, yokucoca, asthenia kakhulu, tachycardia, kunye hypotension nokuba lisibekele.