Yintoni na, "abanesifo RNA uchonge"? Uhlalutyo abanesifo RNA

Angosuleleka hepatitis C singaba. Abantu abaninzi baphila nesi sifo iminyaka kwaye nkqu bazi ukuba ngokusesikweni indlela yokuba kungekudala kube nemiphumela emibi. abantu abanjalo ngenkuthalo ukosulela abanye, kwaye izinga lweziganeko lusoloko kuyanda. Ukunciphisa la manani, umntu kufuneka wenze kube umthetho ukuba bangenele uhlalutyo ngamaxesha kohlobo C, ngakumbi xa usengozini.

inkcazelo emfutshane malunga nesifo

Hepatitis C virus (abanesifo) RNA molecule iqulathe ithwele ulwazi yemfuza kunye neeproteni ezizodwa banxibelelane emzimbeni womntu. ezosulela ngokwabelana kakhulu ngegazi. Kwezinye iimeko, kunokwenzeka transmission nkqo (t. E. Ukusuka kumama ukuya emntwaneni).

Zingene emzimbeni, oko ababeke kwizisele ezahlukeneyo egazini (neutrophils, monocytes, lymphocyte) kunye wesibindi (hepatocytes).

usuleleko nkohliso ukungabikho kweempawu kwesigaba ahlekise. Ngoko nangoko siba nazimpawu ezingapheliyo kwaye kancinane usebenzisa isiphumo yayo ebulalayo.

imiphumela

Ukususela ekuqaleni elalana waya umzimba abanesifo RNA phambi kokuba iimpawu yokuqala kungathatha iminyaka emininzi, maxa wambi iminyaka 15-20 okanye ngaphezulu. Ukuvela izikhalazo okufana iintlobo phambili sohlobo C, xa isibindi sele enokuchatshazelwa kakhulu. Uninzi lwezi izigulana ngoxilongo alandelayo izifo zesibindi:

• ukuqina;
• necrosis;
• cysts ebubonisayo;
• Oncology.

Phambi kuphuhliso iingxaki isigulane usenokuphawula indisposition kancinane, nto leyo zidla baqhoboshele ukubaluleka.

Ukuze afeze uhlalutyo

Uhlalutyo abanesifo RNA luboniswe kubantu bube usulelo. Xa iqela ezinjalo:

• Abaxhomekeki;
• abantu kakubi;
• bonke abenza izenzo ngesondo ngokungakhuselekanga, ingakumbi neqabane entsha;
• abathandi tattoo, ukugqojozwa, zokuzilungisa (beenwele);
• abantu abanikwe Iinkqubo zotyando (kuqukwa ekubelekeni, isifo wamazinyo);
• Wazalwa phambi 1990, oomama nabantwana (into yokuba ngelo xesha esi sifo okwangoku ichongiwe, ngoko ukutofelwa ezi abasetyhini abosulelwe usuleleko);
• Abantwana kunye nomama;
• amalungu osapho kunye nabo ngesondo ezisulelweyo;
• Izigulane abanesifo sesibindi zendalo ezingaziwayo.

Uluhlu kakhulu ebanzi, bambalwa ke ngubani na singatsho ngokuzithemba ukuba ingozi yakhe yosulelo ngu zero.

uvavanyo ekhaya

Abantu abaninzi bangathanda ukuba avavanyelwe ngokuzimisela abanesifo RNA, kodwa hamba uye kwagqirha ngenxa ukuphoxeka, yokungabikho kwexesha, ukungathandi izibhedlele kunye njalo njalo. N.

Kuza kunceda ukusombulula ingxaki loxilongo ezilula usebenzisa kulingwa eyodwa ngokukhawuleza (ELISA). Kulo mzekelo, indlela esemgangathweni umisela kuphela isibakala lobukho antibodies zentsholongwane.

Isebenza kumgaqo lovavanyo ukumisela ukukhulelwa kodwa izinto uvavanyo kufuneka igazi:

1. Gqibezela estrip ngeplastikhi (monitor sokuvavanywa) i Lancet okhethekileyo, lihlaba ngomnwe kwi ngokuthinta iqhosha.
2. Nenxalenye yegazi sokukhetha umbala ibekwe kwindawo gumbi okhethekileyo, yaye emva kwemizuzu 10-15 ukuhlola impendulo.
3. imivalo ezimbini abonisa iziphumo ezidibanisayo, omnye - on the negative. imbonakalo sakuba yechaphaza yesibini kwindawo ukuhlola kubonisa ubukho sifo, nangona kunjalo, uyazikhomba antibodies egazini aphantsi kakhulu.

Ukuba isifo sele ichongiwe, kuyimfuneko ukuba uye kugqirha ukuba uviwo olunye.

Imigaqo ezisisiseko efumanise abanesifo RNA

Ngezi ziphumo kuyimfuneko ukujika kwizifo ezosulelayo kunye hepatology, ngubani na oya kumisela elongeziweyo loviwo.

Eyona nto ibalulekileyo ukuze aphumeze buhlolwe ngokubanzi - ukuchonga apho kweejini ziquka lokufunyanwa kwesibindi, ukuqinisekisa isixa layo egazini. Ukususela data efunyenweyo iya kuxhomekeka unyango ngakumbi, ekubeni zonke iintlobo kwahluka enye kwenye yaye basabela kwiziyobisi. Ukongeza, angenziwa bayakwazi ezigqunyiweyo kakuhle.

iintlobo zophando

Xa uxilongo abanesifo usebenzise enye yezi ndlela zilandelayo:

1. PCR. Kule meko sithetha ngayo umbandela genetic gciwane.
2. Ubuninzi analysis of abanesifo RNA (r-DNK, TMA). Loo Uhlalutyo lwenziwa emva isiqinisekiso ubukho pathogen emzimbeni. Ibizwa kwakhona umthamo wentsholongwane egazini. It ikuvumela ukuba ubone inani labameli yayintsholongwane eyosulela 1 ml igazi. Ukusuka kwezi zalathisi kuxhomekeke ngethuba unyango kunye iqondo infectiousness malunga nesigulane eso. R-DNK yenza uvavanyo kuluhlu phezu 500 ME, kunye TMA kwi 5-10 MNA. zithathwa Zombini ezi ndlela ukuze ibe lula kwaye sitshiphu.
3. Kweejini. It wenza ophelileyo kwaye ikuvumela ukuba ukhankanye ukuba zeziphi iintlobo ziquka kokuchaza sifo.

Ukuhlolwa kweziphumo

Ukuba uhlalutyo abanesifo RNA iyancumisa yi PCR kunye ELISA, uxilongo kuqinisekisiwe. Nakuba kunjalo, isiphumo esithi ayikho ukunika isiqinisekiso ukungabikho usulelo. Ngelishwa, oko kwenzeka kakhulu ngenxa yokuba inkqubo zingasetyenziswa reactants kunye ubuzaza ezahlukeneyo.

Abantu abaninzi bayazibuza ukuba kuthetha ntoni, "abanesifo RNA elibhaqiweyo". Obu bungqina ngempela abonise ukungabikho sifo okanye ingqalelo yayo esezantsi. Umzekelo, i-PCR 200 ME / ML ukunika iziphumo bobuxoki ukuba inani nomonde leekopi egazini kancinane. Oku kunokwenzeka xa kukho usuleleko yakutshanje okanye ngexesha unyango.

Amaxesha amaninzi isigulane akuyomfuneko ukuba olunjalo ulwazi, ekubeni ezi ngongoma kufuneka zithathelwe ingqalelo yi-gqirha khona.

Efumanise abanesifo RNA e uphando oluninzi 400 000 ME nangakumbi ithi le ntsholongwane engekho kuphela egazini, kodwa luqhutywa ngokubonakalayo, ngaloo ndlela nokosulela abanye. Ukuba isalathiso seliza 800 000, oko kubonisa kwisigaba acute kunye neeseli esebenzayo isifo sesibindi.

Nangona kukho uluvo ingcali diverge. Abanye babo bathi ukuba ubuhlobo kunye ngesantya ukuqhubeka kwesifo kunye nenani iikopi zentsholongwane apho.

izigulane ezinjalo kufuneka silumke ngakumbi indlela yokuthetha nabantu ababathandayo.

uphando ezongezelelweyo

Emva kokuba izigqibo abanesifo RNA kunye nezinye izifundo linokukwenziwa nomntu ogulayo, elibandakanya:

• efumanise hepatitis B;
• Uhlalutyo jikelele igazi nomchamo;
• eziphilayo;
• Ultrasound esiswini;
• MRI okanye CT scan kwesibindi (eliboniswe).

Emva kokufumana zonke iinkcukacha eziyimfuneko ugqirha uhlolisisa ngenyameko iziphumo, imo yempilo yesigulane, uze ukhetha scheme unyango ngamnye kuye.

Xa ubhaqo ngexesha umonakalo hepatic, ngokuqhelekileyo emsebenzini.

iindlela kwezonyango namaxesha

Ubude unyango ixhomekeke kwi kweejini. Namhlanje siyazi iintlobo 11 apho 6 ivame kakhulu. Ngo-Russia, i ixhaphakileyo 1, 2 3 uhlobo.

Kwiminyaka embalwa edlulileyo hepatitis C wayephakathi iqela nezifo ezinganyangekiyo. Therapy olwenziwa ikakhulu interferon, akwazi ukuphucula kakhulu imeko yomguli, kodwa ukunyanga ngokupheleleyo.

Impumelelo yonyango sifo iye yaba ichiza "sofosbuvir," esavela ezikhemisti phantsi igama elahlukileyo lorhwebo "Sovaldi". Ukuza kuthi ga ngoku, kukho ezininzi elifanelekileyo analogue:

• "Viropak";
• "Gratitsiano";
• "Geptsinat";
• "Gopetavir".

Ngokufuthi, bathi ukunyamezeleka kakuhle zizigulane, kodwa kwezinye iimeko izinto waphawula:

• intloko ebuhlungu;
• isicaphucaphu;
• ugwayi;
• ukulahleka emnyama;
• yombono;
• migraine;
• ukudana;
• imvakalelo ukoma emlonyeni;
• ubuhlungu esifubeni;
• ukuwa kweenwele.

Le ethile kuphela nyango - (. Umlinganiselo 10 000-12000 p pack ngamnye) ngexabiso eliphezulu kakhulu, Yiphi na, kuxhomekeke medicament ekhethiweyo inokwahluka phezulu okanye ezantsi.

reinvestigation

Emva kokuba unyango, ihlale kwiiveki ezili-12 ukuya ku-24, isigulana siya kunikwa uhlalutyo kuphindwa ubukho RNA wentsholongwane egazini.

Kulo mzekelo, indlela kunye isinyuko ubuncinane uvakalelo kufuneka ingasetyenziswa, ekubeni emva kokuba sesichengeni yoxinaniso ichiza abanesifo inokuba ziyakungahoywa. Kulo mzekelo unyango kufuneka yaqhubeka.

Isiphumo esibi kukungabikho sohlobo C ntsholongwane RNA xa pathogen ibanjiwe. kufuneka esinjalo isifundo ukuba uchithe ixesha elithile ngakumbi (ngamakhefu ezimfutshane), ukuqinisekisa ukuba unyango yimpumelelo.

ukuvimbela

Wonk 'ubani kuye kwaba unyango elide kwaye zibiza imali eninzi hepatitis C, kubalulekile ukukhumbula ukuba umzimba wakhe ongavelisi sifo, ngoko kwakhona kunokwenzeka.

Isifo kulula ukunqanda kunokuba elapha. Ngokupheleleyo uzikhusele ngengozi ayikasebenzi, kodwa ukuze ngoko ke kufuneka ubuze ukuba kuthetha ntoni, "abanesifo RNA elibhaqiweyo", la manyathelo alandelayo kufuneka ziqwalaselwe:

• musa ukusebenzisa izinto ngococeko nabanye abantu (iireyiza, isikere, ngemisonto zamazinyo);
• Kuphephe ngesondo okungakhuselekanga;
• tyelela wamazinyo, izindawo (ubuhle, umvambo, njl ...) kuphela igama elihle;
• avale wonke umonakalo udaka okanye bandage eluswini;
• kangangoko ukuphepha ukudibana nomntu owosulelekileyo.

Outlook

I ngaphambili esi sifo ibhaqwe, i olusebenzayo unyango iya kuba. Ngokuqhelekileyo, xa kungekho lwangaphakathi umbutho hepatitis C sinyangeke ngokupheleleyo kwaye ngaphandle neziphumo.

Ukuba washiya lunganyangwa hepatitis C, yena kungekudala kuya kukhokelela kwesibindi okanye umhlaza wesibindi. Oku kwenzeka iminyaka emva 30-40 emva kokuba bosulelwe yintsholongwane.

Kwesibindi, owayebonakele phantsi kwempembelelo sohlobo C sisifo esingapheliyo esinganyangekiyo. Isaqala kunokwenzeka ukuba isantya flow kwimeko isebenza kuphela onokusindisa isibindi abohlukeneyo kwabantu.

Emva kokufunda lo umphumo omhle kohlobo C, musa ngoko nangoko ukothuka. Okokuqala, kufuneka uhlole imeko isibindi sakho uze aqale ukulwa usulelo kunye comorbidities. Unyango inde kwaye iyabiza, kodwa inika isigulane ithuba kwi ubomi obude nobunempilo.