Drug "Sibutin": imiyalelo ukusetyenziswa, inkcazo kunye nohlolo

isigulane emiselweyo njani yaye nini amayeza "Sibutin"? Imiyalelo yokusebenzisa, isasetyenziswa yokwenene nokubonakaliswa zokusetyenziswa thaca phambili umganyana. Eli nqaku kuyaxoxwa ukwakhiwa ichiza, uhlobo kunye ukukhululwa yayo imiqathango ukusetyenziswa.

Imilo, incazelo kunye nokwakheka

Ukulungiselela "Sibutin", imiyalelo zokusetyenziswa oboniswe apha ngezantsi, iveliswa ngohlobo amacwecwe ngeenxa emhlophe kunye uphawu kwicala elinye. impahla yabo esebenzayo yi oxybutynin (ngokohlobo oxybutynin hydrochloride). Kwakhona le medicament iquka izithako njengesongezelelo ekufundiseni, njengoko zibekiwe uhlobo monohydrate lactose, microcrystalline kwincindi, itapile starch kunye calcium stearate.

iimpawu amayeza we ichiza

wenza njani "Sibutin"? Imiyalelo yokusebenzisa, oogqirha yokwenene ingxelo ukuba indlela amanyathelo kweli chiza kungenxa ngokupheleleyo ukusebenza kwezinto zayo esebenzayo.

Ngokutsho iingcali, "Sibutin" imele blocker receptors M-cholinergic, ngoweqela of amine ephakamileyo. Ngenxa yomsebenzi M-eliphakathi anticholinergic, i-arhente mba ikwazi kuchaphazela ngqo izihlunu agudileyo kwanangezibilini. Ngelo xesha nye na amanyathelo antispasmodic kunye myotropic. Ngamanye amazwi, eli chiza akubikho inkantsi, kwaye kunciphise kwezihlunu le mibutho ilandelayo: iphecana biliary, iphecana zesisu, womchamo, isibeleko kunye isinye. Kufuneka kukhunjulwe ukuba abantu kwekhono neurogenic oxybutynin lokugqibela uyakwazi ukukhulula detrusor, ukunciphisa izishunqulelo yayo zidityaniswe, ukunciphisa nezihlandlo ukuchama, ngokunjalo ukwandisa umthamo lwesinye.

Kinetics kabi

Ezabalazela ngomlomo ingaba loo ndlela njenge "Sibutin"? Imiyalelo yokusebenzisa (inxalenye ichiza laye ezidweliswe phezulu apha) uthi emva ukusetyenziswa amacwecwe oxybutynin ngobulungisa ezabalazela ngokukhawuleza ukusuka lokugaya.

Uphononongo lubonise ukuba xi iphezulu sakhi igazi malunga 8-13 ng / ml. Eli nani kuvamile ukuba iidosi abantu abaselula kunye nempilo mg kwamkelwa 7-10. Kwakhona, kwakukho ukwahluka ngamnye ebalulekileyo umlinganiselo oxybutynin kwi plasma.

Ngenxa sicatshulwa lokuqala isibindi, bioavailability elililo lwenkqubo yemfundo into imalunga 6.2%.

Eyona metabolite ezingundoqo oxybutynin na desethyloxybutynin esebenzayo. Kwakhona kwasekwa kwinkqubo yenguqu, kunye nezinye nezakhi kuquka feniltsiklogeksiglikolevaya acid, nangona kunjalo, ukuba ingasebenzi.

Malunga ne-0,02% wamkela medicament ngesi yokuchama. Unxibelelwano oxybutynin ku albumin imalunga 83-86%, kwaye ixesha layo ezinesiqingatha ubomi iiyure ezimbini.

ukusetyenziswa elide amayeza Ukhuliso yayo esezantsi.

Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi

Xa isigulane linokukwenziwa ku "Sibutin"? Imiyalelo yokusebenzisa (ezibonisa kuya kuxoxwa ngezantsi), ubonelela ukuba ichiza ngokubanzi asetyenziswe ukunyanga ngumchamo wokuchama ngenxa ukusebenza engazinzanga esinyini, leyo yendalo neurogenic (umz, detrusor hyperreflexia, yomqolo eyayimenza okanye multiple) okanye uye uhlobo idiopathic.

Kufuneka kuqatshelwe ukuba ezi ndlela ukuze eboniswe enuresis ebusuku abantwana abaneminyaka emihlanu. Ukulungiselela le njongo medicament isetyenziswa monotherapy, kwaye zidityaniswe kunye namanye amayeza.

Imingcele ukusetyenziswa amacwecwe

Xa kulawula ukuba amayeza isigulane "Sibutin"? Imiyalelo Sebenzisa ithi Izimo ukufumana olu nyango ngaba uthi zilandelayo:

• wamathumbu kokuphazamiseka;
• Hypersensitivity amacandelo indlela;
• atony isisu;
• ukuphazamiseka waveza ukusebenza ukuhamba umchamo lwesinye;
• myasthenia gravis;
• okwenziwa sisilonda sikabhobhosi (elimandundu);
• ukwandiswa ikholoni;
• nokukhulelwa;
• glaucoma;
• lwebele;
• kweminyaka emihlanu.

Drug "Sibutin": imiyalelo yokusebenzisa

Tablets "Sibutin" ezilawulwa kakhulu abadala. Kufuneka uthathe 5 mg kathathu ngemini. izigulane abadala isiyobisi esebenzayo Kucetyiswa ukuba ukusebenzisa isixa mg 5 kabini ngemini.

Kwiimeko ezikhethekileyo, eli yeza liqhutywa kubantwana abangaphantsi kweminyaka emihlanu. Waphula umthetho lwesinye neurogenic uhlobo lokusetyenziswa kweziyobisi 5 mg kabini ngemini, yaye enuresis ebusuku - 5 mg kathathu ngemini. Kulo mzekelo, ithamo yokugqibela kufuneka athathwe phambi lokulala.

imiphumela emibi

Ziintoni abasabela ngayo umlinganiswa ngothabatha ngu amayeza "Sibutin"? Imiyalelo yokusebenzisa ingxelo yokuba uninzi ezi ziphumo kuvela kwi inxalenye lokugaya. Ngenxa umthetho, ukuba kuvela owomileyo umlomo, ukuqhina, isicaphucaphu, ubuhlungu esiswini kunye norhudo.

Kwakhona ingqalelo ichiza kungabangela:

• intloko ebuhlungu, ukungaboni, ukozela, abafundi inimba, isiyezi, ukwanda koxinzelelo intraocular;
• isikhumba owomileyo;
• tide (kwenzeka ikakhulu abantwana), ukugcinwa umchamo, ubunzima uchama, arrhythmia, kunciphise umbilo.

amacala libanda

Ziziphi iimpawu kwenzeka xa libanda, iziyobisi "Sibutin"? Imiyalelo isicelo ithi ezinjalo ziquka ezi zilandelayo: ixhala, ukwanda ubukhali reactions ezibi, ukuphazamiseka, ukusilela bokuphefumla yokujikeleza, wegazi, ukugula ngengqondo, angabikho zingqondweni aze ukushwabana izihlunu zemiphunga.

Kuba unyango kweemeko ezinjalo isicelo lavage esiswini, kwakunye nolawulo efakwa of physostigmine.

Xa wavakalisa excitation okanye ixhala izigulane alawulwa "Diazepam" (w / w, 10 mg) e fever kunyango kwangumqondiso, tachycardia ibonisa ukulungiselela "propranolol" (w / w) nokugcinwa wokuchama ezenziwa catheterization lwesinye, xa ukushwabana izihlunu zemigudu nesiphumo uphuhliso kurarepodobnymi umoya.

Njani oko lisebenzisana nezinye iziyobisi?

Ngaba I ukusebenzisa ezinye iindlela elungiswa "Sibutin"? Imiyalelo isicelo amabango, leyo xa idibene kunye namanye amachiza ingqalelo iyeza kunokubangela reactions icala linyukile. Ngokuqhelekileyo, nomphumela okubhaliweyo ngexesha kunokwamkela "Sibutina" kunye nezenzi ukuba isenzo anticholinergic.

iziyobisi okulalisa kunye ethanol nga negalelo nesiyezi kunye ukozela zandisa.

Kunye nokwamkelwa "itraconazole" oxybutynin kwandisa xiyimiso egazini.

ngexesha lokukhulelwa

Ngaba ngexesha womntwana elindele ukusebenzisa amayeza kuthethwa kunokwenzeka? Ukhuseleko ukusetyenziswa "Sibutina" iye ayasekwa ngeli thuba. Ngoko ke, lo didi izigulane, wathi sithetha elimisiweyo. Kufuneka kuqatshelwe ukuba oxybutynin nga ndicanda ubisi lwebele, ngako oko kufuneka ingasetyenziswa ngexesha zisanyisa. Ukuba nangoku kuyimfuneko, ibele kufuneka kupheliswa.

ulwazi oluthile

Into ekufuneka uyazi isigulana phambi kokusebenzisa iyeza "Sibutin"? Imiyalelo yokusebenzisa (analogue ezidweliswe ngezantsi) ithi ngononophelo kakhulu ichiza kufuneka ufakwe izigulane kakuhle abadala, kwaye izigulane kwizigulo ezimandundu ze izintso wesibindi kunye neuro DYSTONIA.

Kanye njengokuba namanye anticholinergics, kwisicelo "Sibutina" luxwayisa abantu Ithemba uvalo (umngxuma esophageal), nto leyo ilandelwa yi reflux esophagitis.

Ngokuchasene nentsukaphi eli chiza kunokwandisa iziphiwo yomguli kwezonyango arrhythmias, hyperthyroidism, hypertrophy prostatic, isifo kwemithambo kunye nokusilela intliziyo, imvelo esinganyangekiyo.

lobushushu kuma Ukwanda xa usebenzisa ichiza Ingabangela umkhuhlane kunye ukuphazamiseka zentliziyo (kukhokelela ekunciphiseni umbilo).

Abantu abo benza umsebenzi eziyingozi, efuna ingqalelo ekhethekileyo nesantya yokusabela, kuyimfuneko ukuba alumkise ukuba ichiza sifundo kungabangela umbono awucaci kunye ukozela.

Nokubuyekezwa analogue

Analogue beziyobisi sikuwo zezi zilandelayo: "Vesicare," "Detruzitol", "Dream Apo", "Spazmeks", "Driptan", "Zevesin", "Uroholum", "Urotol" kunye nabanye.

Reviews ngale medicament uyakwazi ukuhlangabezana lukhulu. Ezinye izigulane zaye abanelisekanga ukusebenza amayeza. Babanga ukuba ichiza kunceda ukuchama ulawulo, kuquka ebusuku. Noko ke, abantu abaninzi ukhalaze malunga nophuhliso intloko ebuhlungu kunye nezidlo kunye nezinye ngayo elibi. Kulo mba, kufuneka endaweni oko kuthetha analogue ikhuseleke.