"Azathioprine": analogue, ixabiso, isikhokelo kunye nohlolo

isifo samathambo - iqela iimeko zophendlo lwezifo apho kukho ukwanda umsebenzi amajoni omzimba nxamnye nomzimba wakhe. Ukwenzela ukunciphisa omzimba, emiselweyo iziyobisi gqiba amajoni omzimba. Eli qela iziyobisi kuba sele abohlukeneyo ukuthintela lenkohlakalo ukwaliwa. Makhe sijonge ichiza enjalo, njenge "Azathioprine" analogs beziyobisi, kunye nemiyalelo yokusebenzisa iimpawu zayo.

achaza kwemithi

Inxalenye yakhe ichiza "Azathioprine" iqulethe isithako esebenzayo kwegama elifanayo. Le ikhemikhali yi yemvelaphi izinto eziyimfuneko ukuze Yindibanisela DNA kunye RNA. Emzimbeni, azathioprine unika DNA amagama kunye, ngenxa yoko, abangaphangeliyo iinkqubo division iseli kwizihlunu. Ukunciphisa umsebenzi amajoni omzimba okubangelwa yempembelelo iziyobisi "Azathioprine" kwi inyama lymphoid.

Ngenxa yoko kukho inhibition iinkqubo division iseli kunye omzimba zeselula. Emva kokuba kuqaliswe "Azathioprine" ukulungiselela umzimba ukuncitshiswa ezingaqhelekanga inani ziiphagocytes nokuncipha immunoglobulin yokuqaphela. Makhe ngakumbi hlalutya ulwazi: ziziphi iimpawu "Azathioprine" analogue ichiza, ixabiso, nemiyalelo yokusebenzisa.

Pharmacokinetics

Ichiza ngendlela kakhulu bangene yokujikeleza kwegazi, yaye ubuninzi eyavela waphawula emva kweeyure-2 kuphela emva ulawulo ngomlomo. Ichiza engenaso Siyanqumama kwiiproteni plasma: nomphetho wayo kubo ukuya kwi-30%. Kuba ukusebenza uphawu pathways lokuqala azathioprine okanye yokupasa lokuqala esibindini.

Edlula hepatocytes, ichiza umzimba ukuba umchiza - mercaptopurine, kwaye lineziphumo pharmacodynamic. Ukusekwa idubule phantse ngokupheleleyo inyongo. Umchamo idubule yi hayi ngaphezulu kwe-2% of medicament.

Ubungqina obubonakalayo buxela

Ukulungiselela "Azathioprine" analogue kunye ukwimo enye eqhubayo eboniswe zisetyenziswe abohlukeneyo ukuthintela sihlume ukwaliwa reaction.

Kwakhona, ichiza isetyenziswa ngendlela eyiyo practice rheumatological ukunyanga isifo samathambo kunye nezifo samathambo ezifana hepatitis, systemic lupus zomzimba, ukhwekhwe, purpura thrombocytopenic, pemphigus, kunye nabanye abaninzi.

Izimo

"Azathioprine" isiyobisi contraindicated kwizigulane kunye hypersensitivity kwicandelo zeziyobisi. Ngenxa yokuba ichiza abangaphangeliyo zonke iintsholongwane igazi, "Azathioprine" into contraindicated kuzo izifo egazini (anemia leykotsito- kunye lymphopenia, thrombocytopenia), kwakunye wamitha nabongi.

Sebenzisa ngethuba lokukhulelwa lwebele-lwebele

Le into esebenzayo ludlulele ubisi lwebele ngokusebenzisa umqobo gematoplatsentarny. Kulo mba, ukusetyenziswa ayikhuthazwa okhulelwe emabeleni-lwebele. Ukuba kuyimfuneko, ukutyunjwa ichiza okanye analogue zalo kolu didi lwabantu kuyimfuneko ukuhlola umngcipheko ukusuka ukusetyenziswa ukusetyenziswa kweziyobisi kunye nomonakalo ezingayingozi unina kunye olungekazalwa. Xa kunikwa arhente ngexesha lokuncancisa kutshanje ukurhoxisa.

Iimpawu ze isicelo

Ichiza kunye analogs zayo kufuneka ukuba isetyenziswe ngobulumko xa izigulana irhashalala, kwaye izigulane ukuswela xanthine oxidase.

imiphumela emibi

Eyona Iqela iziphumo ebezingalindelekanga ezinxulunyaniswa ne inhibition umsebenzi lomongo wethambo, onoxanduva ekuveliseni iiseli ezibomvu. Ekusebenziseni analogs eziqulathe azathioprine, ukwanda ubungakanani iiseli egazini, ukuncitshiswa leucocyte count, ukubala zegazi, igazi.

Ngokuba ingxenye wokugaya iziphumo ebezingalindelekanga ziqhelekileyo ziquka: yehle wokutya, ukuphazamiseka isitulo, umsebenzi kakuhle hepatic, izilonda sisilonda nesiqephu zesisu. ukulahleka kunokwenzeka of hepatocytes, kulandele ekwandeni yibilirubin okanye ezinye iimvavanyo umsebenzi esibindini. Xa iziguli utyando ukuze nokufakelwa amalungu omzimba kunye zomzimba inokuphuhlisa pancreatitis, izilonda sisilonda esiswini, amathumbu, uphuhliso sohlobo ityhefu.

ziyabagulisa kwenzeka kunqabile kakhulu xa ilawulwa analogs iziyobisi "Azathioprine" isekelwe phezu kwaso (umz: "Azathioprine"). Obubonakala ingachazwayo, ikakhulu ngenxa irhashalala ulusu okanye States bomkhuhlane.

Phakathi kwezinye iziphumo ebezingalindelekanga kufuneka kuqwalaselwe uphuhliso neenkqubo zasesekondari ezosulelayo emzimbeni, imbonakalo intlungu dystrophy kunye namalunga, etsolo sezintso insufficiency esebenza. Kwezinye iimeko kakhulu, ichiza "Azathioprine" analogue kunye into efanayo esebenzayo kunokubangela anemia hemolytic, enika iimpawu ukusuka kwinkqubo luvo. Azathioprine njenge pharmaceutically into esebenzayo, inxalenye igama elifanayo eziyobisi analogue zayo, inefuthe ngokukhawuleza ekukhuleni kosana olungekazalwa (neziphumo yaManzi naMahlathi kunye mutagenic) kwaye bayakwazi ukumqumbisa imbonakalo iinkqubo thumba kunye yobubi babo ezilandelayo. Ngoko ke, kuyimfuneko ukuhlola ukuqeshwa ichiza "Azathioprine" (tablets) ncomo, iinkcazelo, analogue kweziyobisi ukukhetha amaqhinga ekunene. Xa phambili, siphawula ukuba njengoko isithako azathioprine esebenzayo enalo imiphumo eyingenelo kwikhosi ye sifo, ngokutsho nezalathisi. Oku kuboniswa oogqirha nje kuphela kodwa izigulane ngokwabo.

"Azathioprine" - izithethantonye, analogs

Azathioprine - ekhethekileyo ngendlela yawo into yokuba isenzo immunosuppressive. Ngenxa imarike lamachiza ayikho kakhulu amalungiselelo zimelwe kakuhle equlethe azathioprine. Analogs "azathioprine" uyakwazi kwenziwa ichiza enjalo, njenge "Azathioprine".

Ichiza ifumaneka azipilisi enesiqulatho azathioprine efanayo. Le ezincinane kuphela iindleko "Azathioprine" beziyobisi, esingenakubalwa kumaxesha 4-5 iindleko "azathioprine" imveliso Russian.

Ityiwe libanda

Drug libanda, "Azathioprine" kwaye umlingani "Azathioprine" yayo wabonakalaliswa ukuphazamiseka ye phecana zesisu, kwezithandani umsebenzi lomongo wethambo, kwakunye vavanywa kunyuke umsebenzi kwesibindi. unyango Ityhefu njengoko ichiza ngokwayo kunye analogue yayo ibonisa, ezijoliswe ekupheliseni ngokukhawuleza ichiza emzimbeni. Akukho ikhubalo ethile. iindlela dialysis detoxification ziyasebenza ngokuyinxenye ngenxa yokuba into esebenzayo kubo kwazona nje ngokupheleleyo.

oyi

Ichiza kunye analogs yayo akukhuthazwa ukuba zisetyenziswe ixesha elide. Ekuqaleni unyango kufuna esweni rhoqo kwiiseli igazi peripheral, kwakunye nokuhlolwa enqanda zesibindi.

Kwixesha elizayo, kolawulo imihla lwekhefu, ndiqhuba izifundo esweni kanye okanye kabini ngenyanga.

isiphelo

Ichiza kunye analogs yayo eya kumisela liyincutshe onamava kuphela. Ngaphambi kokuba uthathe iindlela eziyimfuneko ukuze bangenele uviwo olupheleleyo mhlawumbi ukuqhuba nonyango yesondlo. Ukuze ufumane inkcazelo engakumbi, kwenza ukuba ukuqeshwa "Azathioprine" imiyalelo ukulungiselela ukusetyenziswa. Price, analogue esi sixhobo njengenxalenye ngumtshangatshangiso kwizigulane. Ngoko ke, ixabiso eliphantsi amacwecwe 50 kummandla ka 250-300 engange, yaye malunga analogue zikhankanywe apha ngasentla. Ngaphambi kokuba kufuneka ahlole "kwizazi" kunye "bawo" kwaye uqale unyango.